| Title: |
Antimicrobial Susceptibility of Clinical Oral Isolates of Actinomyces spp. |
| Authors: |
Alexandra Wolff; Arne C. Rodloff; Paul Vielkind; Toralf Borgmann; Catalina-Suzana Stingu |
| Source: |
Microorganisms, Vol 10, Iss 125, p 125 (2022) |
| Publisher Information: |
MDPI AG |
| Publication Year: |
2022 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
Actinomyces; susceptibility testing; agar dilution; E-Test; Biology (General); QH301-705.5 |
| Description: |
Actinomyces species play an important role in the pathogenesis of oral diseases and infections. Susceptibility testing is not always routinely performed, and one may oversee a shift in resistance patterns. The aim of the study was to analyze the antimicrobial susceptibility of 100 well-identified clinical oral isolates of Actinomyces spp. against eight selected antimicrobial agents using the agar dilution (AD) and E-Test (ET) methods. We observed no to low resistance against penicillin, ampicillin-sulbactam, meropenem, clindamycin, linezolid and tigecycline (0–2% ET, 0% AD) but high levels of resistance to moxifloxacin (93% ET, 87% AD) and daptomycin (83% ET, 95% AD). The essential agreement of the two methods was very good for benzylpenicillin (EA 95%) and meropenem (EA 92%). The ET method was reliable for correctly categorizing susceptibility, in comparison with the reference method agar dilution, except for daptomycin (categorical agreement 87%). Penicillin is still the first-choice antibiotic for therapy of diseases caused by Actinomyces spp. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://www.mdpi.com/2076-2607/10/1/125; https://doaj.org/toc/2076-2607; https://doaj.org/article/7b07ddd983f948a79d287b651a23b866 |
| DOI: |
10.3390/microorganisms10010125 |
| Availability: |
https://doi.org/10.3390/microorganisms10010125; https://doaj.org/article/7b07ddd983f948a79d287b651a23b866 |
| Accession Number: |
edsbas.41C24CD1 |
| Database: |
BASE |