| Title: |
Device-related complications in subcutaneous versus transvenous ICD: a secondary analysis of the PRAETORIAN trial |
| Authors: |
Knops, RE; Pepplinkhuizen, S; Delnoy, PPHM; Boersma, LVA; Kuschyk, J; El-Chami, MF; Bonnemeier, H; Behr, ER; Brouwer, TF; Kaab, S; Mittal, S; Quast, AFBE; van der Stuijt, W; Smeding, L; de Veld, JA; Tijssen, JGP; Bijsterveld, NR; Richter, S; Brouwer, MA; de Groot, JR; Kooiman, KM; Lambiase, PD; Neuzil, P; Vernooy, K; Alings, M; Betts, TR; Bracke, FALE; Burke, MC; de Jong, JSSG; Wright, DJ; Jansen, WPJ; Whinnett, ZI; Nordbeck, P; Knaut, M; Philbert, BT; van Opstal, JM; Chicos, AB; Allaart, CP; Borger van der Burg, AE; Dizon, JM; Miller, MA; Nemirovsky, D; Surber, R; Upadhyay, GA; Weiss, R; de Weger, A; Wilde, AAM; Olde Nordkamp, LRA |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2022 |
| Collection: |
St George's University of London: Repository |
| Description: |
BACKGROUND: The subcutaneous ICD (S-ICD) is developed to overcome lead-related complications and systemic infections, inherent to transvenous ICD (TV-ICD) therapy. The PRAETORIAN trial demonstrated that the S-ICD is non-inferior to the TV-ICD with regard to the combined primary endpoint of inappropriate shocks and complications. This prespecified secondary analysis evaluates all complications in the PRAETORIAN trial. METHODS: The PRAETORIAN trial is an international, multicenter, randomised trial in which 849 patients with an indication for ICD therapy were randomised to receive an SICD (N = 426) or TV-ICD (N = 423) and followed for a median of 49 months. Endpoints were device-related complications, lead-related complications, systemic infections and the need for invasive interventions. RESULTS: Thirty-six device-related complications occurred in 31 patients in the S-ICD group of which bleedings were the most frequent. In the TV-ICD group 49 complications occurred in 44 patients of which lead-dysfunction was most frequent (HR 0.69; P =0.11). In both groups half of all complications were within 30 days after implantation. Lead-related complications and systemic infections occurred significantly less in the S-ICD group compared to the TV-ICD group (P |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| Language: |
English |
| ISSN: |
1522-9645 |
| Relation: |
https://openaccess.sgul.ac.uk/id/eprint/114849/6/ehac496.pdf; https://openaccess.sgul.ac.uk/id/eprint/114849/11/ehac496_supplementary_data.docx; https://openaccess.sgul.ac.uk/id/eprint/114849/1/ehac496.pdf; Knops, RE; Pepplinkhuizen, S; Delnoy, PPHM; Boersma, LVA; Kuschyk, J; El-Chami, MF; Bonnemeier, H; Behr, ER; Brouwer, TF; Kaab, S; et al. Knops, RE; Pepplinkhuizen, S; Delnoy, PPHM; Boersma, LVA; Kuschyk, J; El-Chami, MF; Bonnemeier, H; Behr, ER; Brouwer, TF; Kaab, S; Mittal, S; Quast, AFBE; van der Stuijt, W; Smeding, L; de Veld, JA; Tijssen, JGP; Bijsterveld, NR; Richter, S; Brouwer, MA; de Groot, JR; Kooiman, KM; Lambiase, PD; Neuzil, P; Vernooy, K; Alings, M; Betts, TR; Bracke, FALE; Burke, MC; de Jong, JSSG; Wright, DJ; Jansen, WPJ; Whinnett, ZI; Nordbeck, P; Knaut, M; Philbert, BT; van Opstal, JM; Chicos, AB; Allaart, CP; Borger van der Burg, AE; Dizon, JM; Miller, MA; Nemirovsky, D; Surber, R; Upadhyay, GA; Weiss, R; de Weger, A; Wilde, AAM; Olde Nordkamp, LRA (2022) Device-related complications in subcutaneous versus transvenous ICD: a secondary analysis of the PRAETORIAN trial. Eur Heart J, 43 (47). pp. 4872-4883. ISSN 1522-9645 https://doi.org/10.1093/eurheartj/ehac496 SGUL Authors: Behr, Elijah Raphael |
| DOI: |
10.1093/eurheartj/ehac496 |
| Availability: |
https://openaccess.sgul.ac.uk/id/eprint/114849/; https://openaccess.sgul.ac.uk/id/eprint/114849/6/ehac496.pdf; https://openaccess.sgul.ac.uk/id/eprint/114849/11/ehac496_supplementary_data.docx; https://openaccess.sgul.ac.uk/id/eprint/114849/1/ehac496.pdf; https://doi.org/10.1093/eurheartj/ehac496 |
| Rights: |
cc_by_nc_4 |
| Accession Number: |
edsbas.41E5922C |
| Database: |
BASE |