| Title: |
Quality of life improvement after radiotherapy for bone metastases assessed using real-world data: a secondary analysis of a Nationwide Multicenter Cohort Study |
| Authors: |
Utsumi, Nobuko; Saito, Tetsuo; Shikama, Naoto; Takahashi, Takeo; Harada, Hideyuki; Nakamura, Naoki; Ueno, Shuichi; Notsu, Akifumi; Shirato, Hiroki; Yamada, Kazunari; Uezono, Haruka; Koide, Yutaro; Kubota, Hikaru; Yamazaki, Takuya; Ito, Kei; Heianna, Joichi; Okada, Yukinori; Tonari, Ayako; Katoh, Norio; Wada, Hitoshi; Ejima, Yasuo; Yoshida, Kayo; Kosugi, Takashi; Takahashi, Shigeo; Komiyama, Takafumi; Uchida, Nobue; Miwa, Misako; Watanabe, Miho; Nagakura, Hisayasu; Ikeda, Hiroko; Asakawa, Isao; Shigematsu, Naoyuki |
| Contributors: |
Health Labor Sciences Research Grant from the Ministry of Health, Labor, and Welfare of Japan |
| Source: |
Japanese Journal of Clinical Oncology ; volume 55, issue 2, page 140-147 ; ISSN 1465-3621 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2024 |
| Description: |
Objective Single-center studies or randomized controlled trials have evaluated the impact of radiotherapy for bone metastases on quality of life (QOL). We investigated the real-world impact of radiotherapy for bone metastases on QOL using nationwide multicenter cohort data. Methods We conducted a prospective observational study at 26 centers in Japan. Of 333 patients who received radiotherapy for bone metastases between December 2020 and March 2021, 232 (70%) were enrolled in the study. Patient-reported QOL was evaluated at enrollment and at two- and six-month follow-up using the European Organization for Research and Treatment of Cancer (EORTC) QOL Questionnaire Core 15-Palliative and the EORTC QOL Questionnaire Bone Metastases module (QLQ-BM22). Possible predictors (patient-, tumor -, and treatment-related factors) of QOL improvement were screened using logistic regression models. Results QOL scores showed significant improvement at two-month follow-up in seven (global health status/QOL, emotional functioning, pain, insomnia, painful sites, pain characteristics and functional interference) of the 14 scales. Of these seven scales, mean improvement ≥ the minimal clinically important difference (defined by a change of 10 or more on the 0 to 100 scale) was seen in four scales (pain, insomnia, pain characteristics and functional interference). We did not find any predictors of QOL improvement in the functional interference scale of QLQ-BM22. Conclusion Radiotherapy for bone metastases performed in daily practice is effective in improving some scales of QOL. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/jjco/hyae150 |
| Availability: |
https://doi.org/10.1093/jjco/hyae150; https://academic.oup.com/jjco/article-pdf/55/2/140/60250426/hyae150.pdf |
| Rights: |
https://academic.oup.com/pages/standard-publication-reuse-rights |
| Accession Number: |
edsbas.422AAC7B |
| Database: |
BASE |