| Title: |
Persistent antigenic stimulation alters the transcriptionprogram in T cells, resulting in antigen-specific tolerance |
| Authors: |
Anderson, Per Olof; Manzo, Barbara; Sundstedt, Anette; Minaee, Sophie; Symonds, Alistair; Khalid, Sabah; Rodríguez Cabezas, María Elena; Nicolson, Kirsty; Li, Suling; Wraith, David C.; Wang, Ping |
| Publisher Information: |
Wiley |
| Publication Year: |
2006 |
| Collection: |
DIGIBUG: Repositorio Institucional de la Universidad de Granada |
| Subject Terms: |
T cell tolerance; STAT3; STAT5 |
| Description: |
Repetitive antigen stimulation induces peripheral T cell tolerance in vivo. It is notknown, however, whether multiple stimulations merely suppress T cell activation or,alternatively, change the transcriptional program to a distinct, tolerant state. In thisstudy, we have discovered that STAT3 and STAT5 were activated in response to antigenstimulation in vivo, in marked contrast to the suppression of AP-1, NF-jB and NFAT. Inaddition, a number of transcription factors were induced in tolerant T cells followingantigen challenge in vivo, including T-bet, Irf-1 and Egr-2. The altered transcriptionprogram in tolerant cells associates closely with the suppression of cell cycle progressionand IL-2 production, as well as with the induction of IL-10. Studies of T-bet and Egr-2show that the function of T-bet in peptide treatment-induced regulatory T cells is notassociated with Th1 differentiation, but correlates with the suppression of IL-2, whereasexpression of Egr-2 led to an up-regulation of the cell cycle inhibitors p21 cip1 and p27 kip .Our results demonstrate a balanced transcription program regulated by differenttranscription factors for T cell activation and/or tolerance during antigen-induced T cellresponses. Persistent antigen stimulation can induce T cell tolerance by changing thebalance of transcription factors. ; Wellcome Trust ; Swedish Strategic Research fund ; Barts Foundation for Research ; Brunel University |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://hdl.handle.net/10481/94920 |
| DOI: |
10.1002/eji.200635883 |
| Availability: |
https://hdl.handle.net/10481/94920; https://doi.org/10.1002/eji.200635883 |
| Rights: |
Attribution-NonCommercial-NoDerivatives 4.0 Internacional ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; open access |
| Accession Number: |
edsbas.42566B0F |
| Database: |
BASE |