| Title: |
Cardiovascular changes during peanut-induced allergic reactions in human subjects |
| Authors: |
Ruiz-Garcia, M; Bartra, J; Alvarez, O; Lakhani, A; Patel, S; Tang, A; Sim, M; Shamji, MH; Skypala, I; Mills, ENC; Lyon, AR; Hayward, C; Durham, SR; Turner, PJ; Boyle, RJ |
| Contributors: |
Medical Research Council (MRC); Imperial College Healthcare NHS Trust- BRC Funding; Royal Brompton & Harefield NHS Foundation Trust; Commission of the European Communities; Food Standards Agency; British Heart Foundation |
| Source: |
642 ; 633 |
| Publisher Information: |
Elsevier |
| Publication Year: |
2020 |
| Collection: |
Imperial College London: Spiral |
| Subject Terms: |
Anaphylaxis; cardiac output; cardiovascular; food allergens; intravenous fluids; management; stroke volume; venous return; 1107 Immunology; Allergy |
| Description: |
Background: Food allergy is the commonest cause of anaphylaxis. Changes in posture during acute reactions can trigger fatal outcomes, but the impact of allergic reactions on the cardiovascular system in non-fatal reactions remains poorly understood. Objective: To systematically evaluate changes in cardiovascular function during acute allergic reactions to peanut. Methods: Participants underwent double-blind placebo-controlled food challenge to peanut as part of a clinical trial. Changes in hemodynamic parameters (heart rate, stroke volume, blood pressure, peripheral blood flow) and electrocardiogram during food challenges were assessed using continuous monitoring. ClinicalTrials.gov Identifier: NCT02665793 Results: 57 adults (median age 24 (IQR 20-29) years, 53% female) participated; 22 (39%) had anaphylaxis. Acute reactions were associated with significant changes in stroke volume (mean decrease 4.2%, 95%CI 0.8 to 7.6; p=0.03), heart rate (mean increase 11.6%, 95%CI 8.4 to 14.8; p |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
Journal of Allergy and Clinical Immunology; http://hdl.handle.net/10044/1/80940; MR/K010468/1; ICiC funding 2015/16; N/A; 312147; Cost Centre 1697; RDD02 79560; FS/11/67/28954 |
| DOI: |
10.1016/j.jaci.2020.06.033 |
| Availability: |
http://hdl.handle.net/10044/1/80940; https://doi.org/10.1016/j.jaci.2020.06.033 |
| Rights: |
©2020 The Authors. Published by Elsevier Inc. on behalf of the American Academy ofAllergy, Asthma & Immunology. This is an open access article under the CC BY li-cense (http://creativecommons.org/licenses/by/4.0/). ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.425DF33C |
| Database: |
BASE |