| Title: |
Anopheles stephensi as an emerging malaria vector in the Horn of Africa with high susceptibility to Ethiopian Plasmodium vivax and Plasmodium falciparum isolates |
| Authors: |
Ashine, Temesgen; Teka, Hiwot; Esayas, Endashaw; Messenger, Louisa A; Chali, Wakweya; Meerstein-Kessel, Lisette; Walker, Thomas; Behaksra, Sinknesh Wolde; Lanke, Kjerstin; Heutink, Roel; Jeffries, Claire L; Mekonnen, Daniel Abebe; Hailemeskel, Elifaged; Tebeje, Surafel K; Tafesse, Temesgen; Gashaw, Abrham; Tsegaye, Tizita; Emiru, Tadele; Simon, Kigozi; Bogale, Eyuel Asemahegn; Yohannes, Gedeon; Kedir, Soriya; Shumie, Girma; Sabir, Senya Asfer; Mumba, Peter; Dengela, Dereje; Kolaczinski, Jan H; Wilson, Anne; Churcher, Thomas S; Chibsa, Sheleme; Murphy, Matthew; Balkew, Meshesha; Irish, Seth; Drakeley, Chris; Gadisa, Endalamaw; Bousema, Teun; Tadesse, Fitsum G |
| Publisher Information: |
Cold Spring Harbor Laboratory |
| Publication Year: |
2020 |
| Collection: |
London School of Hygiene & Tropical Medicine: LSHTM Research Online |
| Description: |
Anopheles stephensi , an efficient Asian malaria vector, recently spread into the Horn of Africa and may increase malaria receptivity in African urban areas. We assessed occurrence, genetic complexity, blood meal source and infection status of An. stephensi in Awash Sebat Kilo town, Ethiopia. We used membrane feeding assays to assess competence of local An. stephensi to P. vivax and P. falciparum isolates from clinical patients. 75.3% of the examined waterbodies were infested with An. stephensi developmental stages that were genetically closely related to isolates from Djibouti and Pakistan. Both P. vivax and P. falciparum were detected in wild-caught adult An. stephensi . Local An. stephensi was more receptive to P. vivax compared to a colony of An. arabiensis . We conclude that An. stephensi is an established vector in this part of Ethiopia, highly permissive for local P. vivax and P. falciparum isolates and presents an important new challenge for malaria control. Summary of the article An. stephensi , a metropolitan malaria vector that recently expanded to the Horn of African, was highly susceptible to local P. falciparum and P. vivax isolates from Ethiopia and may increase malariogenic potential of rapidly expanding urban settings in Africa. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://researchonline.lshtm.ac.uk/id/eprint/4656387/1/2020.02.22.961284v1.full.pdf; Ashine, Temesgen; Teka, Hiwot; Esayas, Endashaw; Messenger, Louisa A; Chali, Wakweya; Meerstein-Kessel, Lisette; Walker, Thomas; Behaksra, Sinknesh Wolde; Lanke, Kjerstin; Heutink, Roel; +27 more.Jeffries, Claire L ORCID logo; Mekonnen, Daniel Abebe; Hailemeskel, Elifaged; Tebeje, Surafel K; Tafesse, Temesgen; Gashaw, Abrham; Tsegaye, Tizita; Emiru, Tadele; Simon, Kigozi; Bogale, Eyuel Asemahegn; Yohannes, Gedeon; Kedir, Soriya; Shumie, Girma; Sabir, Senya Asfer; Mumba, Peter; Dengela, Dereje; Kolaczinski, Jan H; Wilson, Anne; Churcher, Thomas S; Chibsa, Sheleme; Murphy, Matthew; Balkew, Meshesha; Irish, Seth; Drakeley, Chris; Gadisa, Endalamaw; Bousema, Teun; and Tadesse, Fitsum G ORCID logo (2020) Anopheles stephensi as an emerging malaria vector in the Horn of Africa with high susceptibility to Ethiopian Plasmodium vivax and Plasmodium falciparum isolates. bioRxiv. DOI:10.1101/2020.02.22.961284 |
| DOI: |
10.1101/2020.02.22.961284 |
| Availability: |
https://researchonline.lshtm.ac.uk/id/eprint/4656387/; https://researchonline.lshtm.ac.uk/id/eprint/4656387/1/2020.02.22.961284v1.full.pdf; https://doi.org/10.1101/2020.02.22.961284 |
| Rights: |
cr_author |
| Accession Number: |
edsbas.429D1EFA |
| Database: |
BASE |