| Title: |
Anticoagulation in sub‐Saharan Africa: Are direct oral anticoagulants the answer? A review of lessons learnt from warfarin |
| Authors: |
Semakula, Jerome Roy; Kisa, Geraldine; Mouton, Johannes P.; Cohen, Karen; Blockman, Marc; Pirmohamed, Munir; Sekaggya‐Wiltshire, Christine; Waitt, Catriona |
| Contributors: |
National Institute for Health Research |
| Source: |
British Journal of Clinical Pharmacology ; volume 87, issue 10, page 3699-3705 ; ISSN 0306-5251 1365-2125 |
| Publisher Information: |
Wiley |
| Publication Year: |
2021 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Warfarin has existed for >7 decades and has been the anticoagulant of choice for many thromboembolic disorders. The recent introduction of direct‐acting oral anticoagulants (DOACs) has, however, caused a shift in preference by healthcare professionals all over the world. DOACs have been found to be at least as effective as warfarin in prevention of stroke in patients with atrial fibrillation and in treatment of venous thromboembolism. In sub‐Saharan Africa, however, the widespread use of DOACs has been hampered mainly by their higher acquisition costs. As the drugs come off patent, their use in sub‐Saharan Africa is likely to increase. However, very few trials have been conducted in African settings, and safety concerns will need to be addressed with further study before widespread adoption into clinical practice. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/bcp.14796 |
| Availability: |
https://doi.org/10.1111/bcp.14796; https://onlinelibrary.wiley.com/doi/pdf/10.1111/bcp.14796; https://onlinelibrary.wiley.com/doi/full-xml/10.1111/bcp.14796; https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/bcp.14796 |
| Rights: |
http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.42BBF18F |
| Database: |
BASE |