| Title: |
Immunological and viral determinants of dengue severity in hospitalized adults in Ha Noi, Viet Nam |
| Authors: |
Fox, A; Hoa, LNM; Simmons, CP; Wolbers, M; Wertheim, HFL; Khuong, PT; Ninh, TTH; Lien, TTM; Lien, NT; Trung, NV; Hien, ND; Farrar, J; Horby, P; Taylor, WR; van Kinh, N |
| Contributors: |
Rico-Hesse, R |
| Publisher Information: |
PUBLIC LIBRARY SCIENCE |
| Publication Year: |
2011 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
BACKGROUND: The relationships between the infecting dengue serotype, primary and secondary infection, viremia and dengue severity remain unclear. This cross-sectional study examined these interactions in adult patients hospitalized with dengue in Ha Noi. METHODS AND FINDINGS: 158 patients were enrolled between September 16 and November 11, 2008. Quantitative RT-PCR, serology and NS1 detection were used to confirm dengue infection, determine the serotype and plasma viral RNA concentration, and categorize infections as primary or secondary. 130 (82%) were laboratory confirmed. Serology was consistent with primary and secondary infection in 34% and 61%, respectively. The infecting serotype was DENV-1 in 42 (32%), DENV-2 in 39 (30%) and unknown in 49 (38%). Secondary infection was more common in DENV-2 infections (79%) compared to DENV-1 (36%, p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
1935-2727 |
| Relation: |
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000288940800006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c; ARTN e967; Fox, A., Hoa, L. N. M., Simmons, C. P., Wolbers, M., Wertheim, H. F. L., Khuong, P. T., Ninh, T. T. H., Lien, T. T. M., Lien, N. T., Trung, N. V., Hien, N. D., Farrar, J., Horby, P., Taylor, W. R. & van Kinh, N. (2011). Immunological and viral determinants of dengue severity in hospitalized adults in Ha Noi, Viet Nam. Plos Neglected Tropical Diseases, 5 (3), https://doi.org/10.1371/journal.pntd.0000967.; https://hdl.handle.net/11343/191114 |
| Availability: |
https://hdl.handle.net/11343/191114; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000288940800006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Accession Number: |
edsbas.42ECEF9C |
| Database: |
BASE |