| Title: |
Predicting 90-day survival of patients with COVID-19: Survival of Severely Ill COVID (SOSIC) scores |
| Authors: |
Schmidt, Matthieu; Guidet, Bertrand; Demoule, Alexandre; Ponnaiah, Maharajah; Fartoukh, Muriel; Puybasset, Louis; Combes, Alain; Hajage, David; Mercat, Alain; Asfar, Pierre; Beloncle, François; Demiselle, Julien; Pham, Tài; Pavot, Arthur; Monnet, Xavier; Richard, Christian; Dres, Martin; Mayaux, Julien; Beurton, Alexandra; Daubin, Cédric; Descamps, Richard; Joret, Aurélie; Du Cheyron, Damien; Pene, Frédéric; Chiche, Jean-Daniel; Jozwiak, Mathieu; Jaubert, Paul; Voiriot, Guillaume; Teulier, Marion; Blayau, Clarisse; L’her, Erwen; Aubron, Cécile; Bodenes, Laetitia; Ferriere, Nicolas; Auchabie, Johann; Le Meur, Anthony; Pignal, Sylvain; Mazzoni, Thierry; Quenot, Jean-Pierre; Andreu, Pascal; Roudau, Jean-Baptiste; Labruyère, Marie; Nseir, Saad; Preau, Sébastien; Poissy, Julien; Mathieu, Daniel; Benhamida, Sarah; Paulet, Rémi; Roucaud, Nicolas; Thyrault, Martial; Daviet, Florence; Hraiech, Sami; Parzy, Gabriel; Sylvestre, Aude; Jochmans, Sébastien; Bouilland, Anne-Laure; Monchi, Mehran; Danguy Des Déserts, Marc; Mathais, Quentin; Rager, Gwendoline; Pasquier, Pierre; Jean, Reignier; Amélie, Seguin; Charlotte, Garret; Emmanuel, Canet; Dellamonica, Jean; Saccheri, Clément; Lombardi, Romain; Kouchit, Yanis; Jacquier, Sophie; Mathonnet, Armelle; Nay, Mai-Ahn; Runge, Isabelle; Martino, Frédéric; Flurin, Laure; Rolle, Amélie; Carles, Michel; Coudroy, Rémi; Thille, Arnaud; Frat, Jean-Pierre; Rodriguez, Maeva; Beuret, Pascal; Tientcheu, Audrey; Vincent, Arthur; Michelin, Florian; Tamion, Fabienne; Carpentier, Dorothée; Boyer, Déborah; Girault, Christophe; Gissot, Valérie; Ehrmann, Stéphan; Salmon Gandonniere, Charlotte; Elaroussi, Djlali; Delbove, Agathe; Fedun, Yannick; Huntzinger, Julien; Lebas, Eddy; Kisoka, Grâce; Grégoire, Céline; Marchetta, Stella; Lambermont, Bernard; Argaud, Laurent; Baudry, Thomas; Bertrand, Pierre-Jean; Dargent, Auguste; Guitton, Christophe; Chudeau, Nicolas; Landais, Mickaël; Darreau, Cédric; Ferre, Alexis; Gros, Antoine; Lacave, Guillaume; Bruneel, Fabrice; Neuville, Mathilde; Devaquet, Jérôme; Tachon, Guillaume; Gallot, Richard; Chelha, Riad; Galbois, Arnaud; Jallot, Anne; Chalumeau Lemoine, Ludivine; Kuteifan, Khaldoun; Pointurier, Valentin; Jandeaux, Louise-Marie; Mootien, Joy; Damoisel, Charles; Sztrymf, Benjamin; Chommeloux, Juliette; Luyt, Charles-Edouard; Schortgen, Frédérique; Rusel, Leon; Jung, Camille; Gobert, Florent; Vimpere, Damien; Lamhaut, Lionel; Sauneuf, Bertrand; Charrrier, Liliane; Calus, Julien; Desmeules, Isabelle; Painvin, Benoît; Tadie, Jean-Marc; Castelain, Vincent; Michard, Baptiste; Herbrecht, Jean-Etienne; Baldacini, Mathieu; Weiss, Nicolas; Demeret, Sophie; Marois, Clémence; Rohaut, Benjamin; Moury, Pierre-Henri; Savida, Anne-Charlotte; Couadau, Emmanuel; Série, Mathieu; Alexandru, Nica; Bruel, Cédric; Fontaine, Candice; Garrigou, Sonia; Courtiade Mahler, Juliette; Leclerc, Maxime; Ramakers, Michel; Garçon, Pierre; Massou, Nicole; van Vong, Ly; Sen, Juliane; Lucas, Nolwenn; Chemouni, Franck; Stoclin, Annabelle; Avenel, Alexandre; Faure, Henri; Gentilhomme, Angélie; Ricome, Sylvie; Abraham, Paul; Monard, Céline; Textoris, Julien; Rimmele, Thomas; Montini, Florent; Lejour, Gabriel; Lazard, Thierry; Etienney, Isabelle; Kerroumi, Younes; Dupuis, Claire; Bereiziat, Marine; Coupez, Elisabeth; Thouy, François; Hoffmann, Clément; Donat, Nicolas; Chrisment, Anne; Blot, Rose-Marie; Kimmoun, Antoine; Jacquot, Audrey; Mattei, Matthieu; Levy, Bruno; Ravan, Ramin; Dopeux, Loïc; Liteaudon, Jean-Mathias; Roux, Delphine; Rey, Brice; Anghel, Radu; Schenesse, Deborah; Gevrey, Vincent; Castanera, Jermy; Petua, Philippe; Madeux, Benjamin; Hartman, Otto; Piagnerelli, Michael; Joosten, Anne; Noel, Cinderella; Biston, Patrick; Noel, Thibaut; Bouar, Gurvan; Boukhanza, Messabi; Demarest, Elsa; Bajolet, Marie-France; Charrier, Nathanaël; Quenet, Audrey; Zylberfajn, Cécile; Dufour, Nicolas; Mégarbane, Buno; Voicu, Sqébastian; Deye, Nicolas; Malissin, Isabelle; Legay, François; Debarre, Matthieu; Barbarot, Nicolas; Fillatre, Pierre; Delord, Bertrand; Laterrade, Thomas; Saghi, Tahar; Pujol, Wilfried; Cungi, Pierre-Julien; Esnault, Pierre; Cardinale, Mickael; Hong Tuan Ha, Vivien; Fleury, Grégory; Brou, Marie-Ange; Zafimahazo, Daniel; Tran-Van, David; Avargues, Patrick; Carenco, Lisa; Robin, Nicolas; Ouali, Alexandre; Houdou, Lucie; Le Terrier, Christophe; Suh, Noémie; Primmaz, Steve; Pugin, Jérome; Weiss, Emmanuel; Gauss, Tobias; Moyer, Jean-Denis; Paugam Burtz, Catherine; La Combe, Béatrice; Smonig, Rolland; Violleau, Jade; Cailliez, Pauline; Chelly, Jonathan; Marchalot, Antoine; Saladin, Cécile; Bigot, Christelle; Fayolle, Pierre-Marie; Fatséas, Jules; Ibrahim, Amr; Resiere, Dabor; Hage, Rabih; Cholet, Clémentine; Cantier, Marie; Trouiler, Pierre; Montravers, Philippe; Lortat-Jacob, Brice; Tanaka, Sebastien; Tran Dinh, Alexy; Duranteau, Jacques; Harrois, Anatole; Dubreuil, Guillaume; Werner, Marie; Godier, Anne; Hamada, Sophie; Zlotnik, Diane; Nougue, Hélène; Mekontso-Dessap, Armand; Carteaux, Guillaume; Razazi, Keyvan; de Prost, Nicolas; Mongardon, Nicolas; Langeron, Olivier; Levesque, Eric; Attias, Arié; de Roquetaillade, Charles; Chousterman, Benjamin; Mebazaa, Alexandre; Gayat, Etienne; Garnier, Marc; Pardo, Emmanuel; Satre-Buisson, Lea; Gutton, Christophe; Yvin, Elise; Marcault, Clémence; Azoulay, Elie; Darmon, Michael; Ait Oufella, Hafid; Hariri, Geoffroy; Urbina, Tomas; Mazerand, Sandie; Heming, Nicholas; Santi, Francesca; Moine, Pierre; Annane, Djillali; Bouglé, Adrien; Omar, Edris; Lancelot, Aymeric; Begot, Emmanuelle; Plantefeve, Gaétan; Contou, Damien; Mentec, Hervé; Pajot, Olivier; Faguer, Stanislas; Cointault, Olivier; Lavayssiere, Laurence; Nogier, Marie-Béatrice; Jamme, Matthieu; Pichereau, Claire; Hayon, Jan; Outin, Hervé; Dépret, François; Coutrot, Maxime; Chaussard, Maité; Guillemet, Lucie; Goffin, Pierre; Thouny, Romain; Guntz, Julien; Jadot, Laurent; Persichini, Romain; Jean-Michel, Vanessa; Georges, Hugues; Caulier, Thomas; Pradel, Gaël; Hausermann, Marie-Hélène; Nguyen-Valat, Thi My Hue; Boudinaud, Michel; Vivier, Emmanuel; Rosseli, Sylvène; Bourdin, Gaël; Pommier, Christian; Vinclair, Marc; Poignant, Simon; Mons, Sandrine; Bougouin, Wulfran; Bruna, Franklin; Maestraggi, Quentin; Roth, Christian; Bitker, Laurent; Dhelft, François; Bonnet-Chateau, Justine; Filippelli, Mathilde; Morichau-Beauchant, Tristan; Thierry, Stéphane; Le Roy, Charlotte; Saint Jouan, Mélanie; Goncalves, Bruno; Mazeraud, Aurélien; Daniel, Matthieu; Sharshar, Tarek; Cadoz, Cyril; Gaci, Rostane; Gette, Sébastien; Louis, Guillaune; Sacleux, Sophe-Caroline; Ordan, Marie-Amélie; Cravoisy, Aurélie; Conrad, Marie; Courte, Guilhem; Gibot, Sébastien; Benzidi, Younès; Casella, Claudia; Serpin, Laurent; Setti, Jean-Lou; Besse, Marie-Catherine; Bourreau, Anna; Pillot, Jérôme; Rivera, Caroline; Vinclair, Camille; Robaux, Marie-Aline; Achino, Chloé; Delignette, Marie-Charlotte; Mazard, Tessa; Aubrun, Frédéric; Bouchet, Bruno; Frérou, Aurélien; Muller, Laura; Quentin, Charlotte; Degoul, Samuel; Stihle, Xavier; Sumian, Claude; Bergero, Nicoletta; Lanaspre, Bernard; Quintard, Hervé; Maiziere, Eve Marie; Egreteau, Pierre-Yves; Leloup, Guillaume; Berteau, Florin; Cottrel, Marjolaine; Bouteloup, Marie; Jeannot, Matthieu; Blanc, Quentin; Saison, Julien; Geneau, Isabelle; Grenot, Romaric; Ouchike, Abdel; Hazera, Pascal; Masse, Anne-Lyse; Demiri, Suela; Vezinet, Corinne; Baron, Elodie; Benchetrit, Deborah; Monsel, Antoine; Trebbia, Grégoire; Schaack, Emmanuelle; Lepecq, Raphaël; Bobet, Mathieu; Vinsonneau, Christophe; Dekeyser, Thibault; Delforge, Quentin; Rahmani, Imen; Vivet, Bérengère; Paillot, Jonathan; Hierle, Lucie; Chaignat, Claire; Valette, Sarah; Her, Benoït; Brunet, Jennifier; Page, Mathieu; Boiste, Fabienne; Collin, Anthony; Bavozet, Florent; Garin, Aude; Dlala, Mohamed; Mhamdi, Kais; Beilouny, Bassem; Lavalard, Alexandra; Perez, Severine; Veber, Benoit; Guitard, Pierre-Gildas; Gouin, Philippe; Lamacz, Anna; Plouvier, Fabienne; Delaborde, Bertrand; Kherchache, Aïssa; Chaalal, Amina; Ricard, Jean-Damien; Amouretti, Marc; Freita-Ramos, Santiago; Roux, Damien; Constantin, Jean-Michel; Assefi, Mona; Lecore, Marine; Selves, Agathe; Prevost, Florian; Lamer, Christian; Shi, Ruiying; Knani, Lyes; Pili Floury, Sébastien; Vettoretti, Lucie; Levy, Michael; Marsac, Lucile; Dauger, Stéphane; Guilmin-Crépon, Sophie; Winiszewski, Hadrien; Piton, Gael; Soumagne, Thibaud; Capellier, Gilles; Putegnat, Jean-Baptiste; Bayle, Frédérique; Perrou, Maya; Thao, Ghyslaine; Géri, Guillaume; Charron, Cyril; Repessé, Xavier; Vieillard-Baron, Antoine; Guilbart, Mathieu; Roger, Pierre-Alexandre; Hinard, Sébastien; Macq, Pierre-Yves; Chaulier, Kevin; Goutte, Sylvie; Chillet, Patrick; Pitta, Anaïs; Darjent, Barbara; Bruneau, Amandine; Lasocki, Sigismond; Leger, Maxime; Gergaud, Soizic; Lemarie, Pierre; Terzi, Nicolas; Schwebel, Carole; Dartevel, Anaïs; Galerneau, Louis-Marie; Diehl, Jean-Luc; Hauw-Berlemont, Caroline; Péron, Nicolas; Guérot, Emmanuel; Mohebbi Amoli, Abolfazl; Benhamou, Michel; Deyme, Jean-Pierre; Andremont, Olivier; Lena, Diane; Cady, Julien; Causeret, Arnaud; de la Chapelle, Arnaud; Cracco, Christophe; Rouleau, Stéphane; Schnell, David; Foucault, Camille; Lory, Cécile; Chapelle, Thibault; Bruckert, Vincent; Garcia, Julie; Sahraoui, Abdlazize; Abbosh, Nathalie; Bornstain, Caroline; Pernet, Pierre; Poirson, Florent; Pasem, Ahmed; Karoubi, Philippe; Poupinel, Virginie; Gauthier, Caroline; Bouniol, François; Feuchere, Philippe; Heron, Anne; Carreira, Serge; Emery, Malo; Le Floch, Anne Sophie; Giovannangeli, Luana; Herzog, Nicolas; Giacardi, Christophe; Baudic, Thibaut; Thill, Chloé; Lebbah, Said; Palmyre, Jessica; Tubach, Florence; Bonnet, Nicolas; Ebstein, Nathan; Gaudry, Stéphane; Cohen, Yves; Noublanche, Julie; Lesieur, Olivier; Sément, Arnaud; Roca-Cerezo, Isabel; Pascal, Michel; Sma, Nesrine; Colin, Gwenhaël; Lacherade, Jean-Claude; Bionz, Gauthier; Maquigneau, Natacha; Bouzat, Pierre; Durand, Michel; Hérault, Marie-Christine; Payen, Jean-Francois |
| Contributors: |
Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition CHU Pitié Salpêtrière (IHU ICAN); CHU Pitié-Salpêtrière AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); Groupe de recherche cinique Réanimation et soins intensifs du patient en Insuffisance respiratoire aigüe (GRC 30 - RESPIRE); Sorbonne Université (SU); Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP); Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU); Neurophysiologie Respiratoire Expérimentale et Clinique (UMRS 1158); CHU Tenon AP-HP; Sorbonne Université - Faculté de Médecine (SU FM); Laboratoire d'Imagerie Biomédicale Paris (LIB); Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS); Centre d'investigation clinique Paris Est CHU Pitié Salpêtrière (CIC Paris-Est); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); Centre Hospitalier Universitaire d'Angers (CHU Angers); LUNAM Université Nantes Angers Le Mans; CHU d'Angers Département Urgences; MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC); Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Centre Hospitalier Universitaire Strasbourg (CHU Strasbourg); Hôpitaux Universitaires de Strasbourg (HUS); Fédération de Médecine Translationnelle de Strasbourg (FMTS); Université de Strasbourg (UNISTRA); Nanomédecine Régénérative (NanoRegMed); Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM); Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Faculté de Médecine Paris-Saclay; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Saclay; Groupe de recherche clinique CARMAS (Cardiovascular and Respiratory Manifestations of Acute lung injury and Sepsis) (CARMAS); Institut Mondor de Recherche Biomédicale (IMRB); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-CHU Henri Mondor Créteil; Groupe Henri Mondor-Albert Chenevier-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Henri Mondor-Albert Chenevier-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Hypertension pulmonaire : physiopathologie et innovation thérapeutique (HPPIT); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay; CHU Charles Foix AP-HP; GIN Grenoble Institut des Neurosciences (GIN); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA); Université Grenoble Alpes (UGA); This study was funded by the Fondation APHP and its donators though the program “Alliance Tous Unis Contre le Virus”, the Direction de la Recherche Clinique et du Développement, and the French Ministry of Health. The Reseau European de recherche en Ventilation Artificielle (REVA) network received a 75,000 € research grant from Air Liquide Healthcare. The funders had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. The sponsor was Assistance Publique Hôpitaux de Paris (APHP). |
| Source: |
ISSN: 2110-5820 ; Annals of Intensive Care ; https://hal.science/hal-04821035 ; Annals of Intensive Care, 2021, 11 (1), pp.170. ⟨10.1186/s13613-021-00956-9⟩. |
| Publisher Information: |
CCSD; SpringerOpen |
| Publication Year: |
2021 |
| Subject Terms: |
Outcome; Acute respiratory distress syndrome; COVID-19; Mechanical ventilation; Predictive survival model; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Description: |
International audience ; Background: Predicting outcomes of critically ill intensive care unit (ICU) patients with coronavirus-19 disease (COVID-19) is a major challenge to avoid futile, and prolonged ICU stays. Methods: The objective was to develop predictive survival models for patients with COVID-19 after 1-to-2 weeks in ICU. Based on the COVID-ICU cohort, which prospectively collected characteristics, management, and outcomes of critically ill patients with COVID-19. Machine learning was used to develop dynamic, clinically useful models able to predict 90-day mortality using ICU data collected on day (D) 1, D7 or D14. Results: Survival of Severely Ill COVID (SOSIC)-1, SOSIC-7, and SOSIC-14 scores were constructed with 4244, 2877, and 1349 patients, respectively, randomly assigned to development or test datasets. The three models selected 15 ICU-entry variables recorded on D1, D7, or D14. Cardiovascular, renal, and pulmonary functions on prediction D7 or D14 were among the most heavily weighted inputs for both models. For the test dataset, SOSIC-7's area under the ROC curve was slightly higher (0.80 [0.74-0.86]) than those for SOSIC-1 (0.76 [0.71-0.81]) and SOSIC-14 (0.76 [0.68-0.83]). Similarly, SOSIC-1 and SOSIC-7 had excellent calibration curves, with similar Brier scores for the three models. Conclusion: The SOSIC scores showed that entering 15 to 27 baseline and dynamic clinical parameters into an automatable XGBoost algorithm can potentially accurately predict the likely 90-day mortality post-ICU admission (sosic.shinyapps.io/shiny). Although external SOSIC-score validation is still needed, it is an additional tool to strengthen decisions about life-sustaining treatments and informing family members of likely prognosis. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/34897559; PUBMED: 34897559; PUBMEDCENTRAL: PMC8665857 |
| DOI: |
10.1186/s13613-021-00956-9 |
| Availability: |
https://hal.science/hal-04821035; https://hal.science/hal-04821035v1/document; https://hal.science/hal-04821035v1/file/Schmidt_2021.pdf; https://doi.org/10.1186/s13613-021-00956-9 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.4341FF7F |
| Database: |
BASE |