| Title: |
Cerebral toxoplasmosis in the twenty-first century:long-term clinical outcomes in a retrospective cohort study in the Netherlands |
| Authors: |
van Deuzen, C. M.; Rijnders, B. J.A.; Bax, H. I.; Rokx, C.; de Vries-Sluijs, T. E.M.S.; Schurink, C. A.M.; Nouwen, J. L.; de Mendonça-Melo, M.; Anas, A. A.; van Gorp, E.; Slobbe, L.; van Hellemond, J. J.; van Nood, E. |
| Source: |
van Deuzen, C M, Rijnders, B J A, Bax, H I, Rokx, C, de Vries-Sluijs, T E M S, Schurink, C A M, Nouwen, J L, de Mendonça-Melo, M, Anas, A A, van Gorp, E, Slobbe, L, van Hellemond, J J & van Nood, E 2025, 'Cerebral toxoplasmosis in the twenty-first century : long-term clinical outcomes in a retrospective cohort study in the Netherlands', AIDS, vol. Publish Ahead of Print. https://doi.org/10.1097/QAD.0000000000004356 |
| Publication Year: |
2025 |
| Subject Terms: |
/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being; name=SDG 3 - Good Health and Well-being |
| Description: |
Background: – Cerebral toxoplasmosis is a common opportunistic infection in people with HIV (PWH), associated with high morbidity and mortality. It is unclear how clinical characteristics, treatment response and long-term clinical outcomes in PWH with cerebral toxoplasmosis have changed due to improved treatment of HIV. Methods: – This single-centre retrospective observational cohort study of PWH with cerebral toxoplasmosis included patients over almost 25 years. Results: – 63 eligible patients were identified. Most patients were late presenters presenting with headache and neurological symptoms. Overall survival was 79% over a mean follow up of 15 years. 73% of deaths occurred within the first year after diagnosis. Almost 10% of patients experienced residual impairments. Conclusions: – An earlier diagnosis of HIV reduces the incidence of cerebral toxoplasmosis due to timely initiation of cART and anti-Toxoplasma prophylaxis. High index of suspicion by clinicians is vital to timely start anti-Toxoplasma therapy. If treated correctly and timely, overall survival is high. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
0269-9370; 1473-5571 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40985660; info:eu-repo/semantics/altIdentifier/pissn/0269-9370; info:eu-repo/semantics/altIdentifier/eissn/1473-5571 |
| DOI: |
10.1097/QAD.0000000000004356 |
| Availability: |
https://pure.eur.nl/en/publications/a92b93ce-b05d-4c40-a808-f05822360369; https://doi.org/10.1097/QAD.0000000000004356; https://pure.eur.nl/ws/files/216909109/cerebral_toxoplasmosis_in_the_twenty_first.786.pdf; https://www.scopus.com/pages/publications/105023648935 |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.4356CA20 |
| Database: |
BASE |