| Title: |
Heart failure in COVID-19: the multicentre, multinational PCHF-COVICAV registry |
| Authors: |
Sokolski, Mateusz; Trenson, Sander; Sokolska, Justyna M; D'Amario, Domenico; Meyer, Philippe; Poku, Nana Kwabena; Biering-Sørensen, Tor; Højbjerg Lassen, Mats C; Skaarup, Kristoffer G; Barge-Caballero, Eduardo; Pouleur, Anne-Catherine; Stolfo, Davide; Sinagra, Gianfranco; Ablasser, Klemens; Muster, Viktoria; Rainer, Peter P; Wallner, Markus; Chiodini, Alessandra; Heiniger, Pascal S; Mikulicic, Fran; Schwaiger, Judith; Winnik, Stephan; Cakmak, Huseyin A; Gaudenzi, Margherita; Mapelli, Massimo; Mattavelli, Irene; Paul, Matthias; Cabac-Pogorevici, Irina; Bouleti, Claire; Lilliu, Marzia; Minoia, Chiara; Dauw, Jeroen; Costa, Jérôme; Celik, Ahmet; Mewton, Nathan; Montenegro, Carlos E L; Matsue, Yuya; Loncar, Goran; Marchel, Michal; Bechlioulis, Aris; Michalis, Lampros; Dörr, Marcus; Prihadi, Edgard; Schoenrath, Felix; Messroghli, Daniel R; Mullens, Wilfried; Lund, Lars H; Rosano, Giuseppe M C; Ponikowski, Piotr; Ruschitzka, Frank; Flammer, Andreas J |
| Source: |
ISSN: 2055-5822 ; ESC heart failure, vol. 8, no. 6 (2021) p. 4955-4967. |
| Publication Year: |
2021 |
| Collection: |
Université de Genève: Archive ouverte UNIGE |
| Subject Terms: |
info:eu-repo/classification/ddc/616; COVID-19; Cardiovascular disease; Heart failure; Risk factors; SARS-CoV2; Aged; Female; Heart Failure / epidemiology; Hospital Mortality; Humans; Male; Registries; Retrospective Studies; SARS-CoV-2 |
| Description: |
Aims: We assessed the outcome of hospitalized coronavirus disease 2019 (COVID-19) patients with heart failure (HF) compared with patients with other cardiovascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia). We further wanted to determine the incidence of HF events and its consequences in these patient populations. Methods and results: International retrospective Postgraduate Course in Heart Failure registry for patients hospitalized with COVID-19 and CArdioVascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia) was performed in 28 centres from 15 countries (PCHF-COVICAV). The primary endpoint was in-hospital mortality. Of 1974 patients hospitalized with COVID-19, 1282 had cardiovascular disease and/or risk factors (median age: 72 [interquartile range: 62-81] years, 58% male), with HF being present in 256 [20%] patients. Overall in-hospital mortality was 25% (n = 323/1282 deaths). In-hospital mortality was higher in patients with a history of HF (36%, n = 92) compared with non-HF patients (23%, n = 231, odds ratio [OR] 1.93 [95% confidence interval: 1.44-2.59], P < 0.001). After adjusting, HF remained associated with in-hospital mortality (OR 1.45 [95% confidence interval: 1.01-2.06], P = 0.041). Importantly, 186 of 1282 [15%] patients had an acute HF event during hospitalization (76 [40%] with de novo HF), which was associated with higher in-hospital mortality (89 [48%] vs. 220 [23%]) than in patients without HF event (OR 3.10 [2.24-4.29], P < 0.001). Conclusions: Hospitalized COVID-19 patients with HF are at increased risk for in-hospital death. In-hospital worsening of HF or acute HF de novo are common and associated with a further increase in in-hospital mortality. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/34533287; unige:161566 |
| Availability: |
https://archive-ouverte.unige.ch/unige:161566 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.442E7704 |
| Database: |
BASE |