Detection of Lung Dysfunction Using Ventilation and Perfusion SPECT in a Mouse Model of Chronic Cigarette Smoke Exposure
| Title: | Detection of Lung Dysfunction Using Ventilation and Perfusion SPECT in a Mouse Model of Chronic Cigarette Smoke Exposure |
|---|---|
| Authors: | Rod G. Rhem; Iris Q. Wang; William B. Counter; Martin R. Stämpfli; N. Renée Labiris |
| Contributors: | The Pennsylvania State University CiteSeerX Archives |
| Source: | http://interactive.snm.org/docs/JNM_Article_April_2013.pdf. |
| Collection: | CiteSeerX |
| Description: | Chronic obstructive pulmonary disease is a leading cause of morbidity and mortality worldwide. Exposure to cigarette smoke (CS) is a major risk factor for developing this chronic airflow impairment, but the early progression of disease is not well defined or understood. Ventilation/perfusion (V/Q) SPECT pro-vides a noninvasive assessment of lung function to further our current understanding of how CS affects the lung. Methods: BALB/c mice were imaged with V/Q SPECT and CT after 8 and 24 wk of whole-body exposure to mainstream CS. Bron-choalveolar lavage was collected and cell differentials produced to determine inflammatory patterns. Histologic lung sections were collected, and a semiautomated quantitative analysis of airspace enlargement was applied to whole histology slices. Results: Exposure to CS induced an inflammatory response that included increases in the numbers of both mononuclear cells |
| Document Type: | text |
| File Description: | application/pdf |
| Language: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.648.6418; http://interactive.snm.org/docs/JNM_Article_April_2013.pdf |
| Availability: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.648.6418; http://interactive.snm.org/docs/JNM_Article_April_2013.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| Accession Number: | edsbas.4495096C |
| Database: | BASE |