| Title: |
Family history of colorectal cancer and survival: a Swedish population‐based study |
| Authors: |
Pesola, F.; Eloranta, S.; Martling, A.; Saraste, D.; Smedby, K. E. |
| Contributors: |
Cancer Research UK |
| Source: |
Journal of Internal Medicine ; volume 287, issue 6, page 723-733 ; ISSN 0954-6820 1365-2796 |
| Publisher Information: |
Wiley |
| Publication Year: |
2020 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Objectives A family history of colorectal cancer (CRC) is an established risk factor for developing CRC, whilst the impact of family history on prognosis is unclear. The present study assessed the association between family history and prognosis and, based on current evidence, explored whether this association was modified by age at diagnosis. Methods Using data from the Swedish Colorectal Cancer Registry (SCRCR) linked with the Multigeneration Register and the National Cancer Register, we identified 31 801 patients with a CRC diagnosed between 2007 and 2016. The SCRCR is a clinically rich database which includes information on the cancer stage, grade, location, treatment, complications and postoperative follow‐up. Results We estimated excess mortality rate ratios (EMRR) for relative survival and hazard ratios (HR) for disease‐free survival with 95% confidence intervals (CIs) using flexible parametric models. We found no association between family history and relative survival (EMRR = 0.96, 95% CIs: 0.89–1.03, P = 0.21) or disease‐free survival (HR = 0.98, 95% CIs: 0.91–1.06, P = 0.64). However, age was found to modify the impact of family history on prognosis. Young patients ( |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/joim.13036 |
| Availability: |
https://doi.org/10.1111/joim.13036; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjoim.13036; https://onlinelibrary.wiley.com/doi/pdf/10.1111/joim.13036; https://onlinelibrary.wiley.com/doi/full-xml/10.1111/joim.13036 |
| Rights: |
http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.44ADCEF3 |
| Database: |
BASE |