| Title: |
Predictors of mortality in hospital survivors with type 2 diabetes mellitus and acute coronary syndromes |
| Authors: |
Savonitto S; Morici N; Nozza A; Cosentino F; Perrone Filardi P; Murena E; Morocutti G; Ferri M; Cavallini C; Eijkemans MJ; Stähli BE; Schrieks IC; Toyama T; Lambers Heerspink HJ; Malmberg K; Schwartz GG; Lincoff AM; Ryden L; Tardif JC; Grobbee DE |
| Contributors: |
Savonitto, S; Morici, N; Nozza, A; Cosentino, F; Perrone Filardi, P; Murena, E; Morocutti, G; Ferri, M; Cavallini, C; Eijkemans, Mj; Stähli, Be; Schrieks, Ic; Toyama, T; Lambers Heerspink, Hj; Malmberg, K; Schwartz, Gg; Lincoff, Am; Ryden, L; Tardif, Jc; Grobbee, De |
| Publisher Information: |
SAGE Publications Ltd |
| Publication Year: |
2018 |
| Collection: |
Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: |
acute coronary syndrome; mortality; diabetes mellitus |
| Description: |
Aim: To define the predictors of long-term mortality in patients with type 2 diabetes mellitus and recent acute coronary syndrome. Methods and results: A total of 7226 patients from a randomized trial, testing the effect on cardiovascular outcomes of the dual peroxisome proliferator–activated receptor agonist aleglitazar in patients with type 2 diabetes mellitus and recent acute coronary syndrome (AleCardio trial), were analysed. Median follow-up was 2 years. The independent mortality predictors were defined using Cox regression analysis. The predictive information provided by each variable was calculated as percent of total chi-square of the model. All-cause mortality was 4.0%, with cardiovascular death contributing for 73% of mortality. The mortality prediction model included N-terminal proB-type natriuretic peptide (adjusted hazard ratio = 1.68; 95% confidence interval = 1.51–1.88; 27% of prediction), lack of coronary revascularization (hazard ratio = 2.28; 95% confidence interval = 1.77–2.93; 18% of prediction), age (hazard ratio = 1.04; 95% confidence interval = 1.02–1.05; 15% of prediction), heart rate (hazard ratio = 1.02; 95% confidence interval = 1.01–1.03; 10% of prediction), glycated haemoglobin (hazard ratio = 1.11; 95% confidence interval = 1.03–1.19; 8% of prediction), haemoglobin (hazard ratio = 1.01; 95% confidence interval = 1.00–1.02; 8% of prediction), prior coronary artery bypass (hazard ratio = 1.61; 95% confidence interval = 1.11–2.32; 7% of prediction) and prior myocardial infarction (hazard ratio = 1.40; 95% confidence interval = 1.05–1.87; 6% of prediction). Conclusion: In patients with type 2 diabetes mellitus and recent acute coronary syndrome, mortality prediction is largely dominated by markers of cardiac, rather than metabolic, dysfunction. |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/29052439; info:eu-repo/semantics/altIdentifier/wos/WOS:000418380200002; volume:15; issue:1; firstpage:14; lastpage:23; numberofpages:10; journal:DIABETES & VASCULAR DISEASE RESEARCH; http://hdl.handle.net/11573/1088601 |
| DOI: |
10.1177/1479164117735493 |
| Availability: |
http://hdl.handle.net/11573/1088601; https://doi.org/10.1177/1479164117735493 |
| Rights: |
info:eu-repo/semantics/closedAccess |
| Accession Number: |
edsbas.44C2EC2A |
| Database: |
BASE |