| Title: |
Structure, Biosynthesis, and Biological Activity of the Cyclic Lipopeptide Anikasin |
| Authors: |
Götze, S.; Herbst Irmer, R.; Klapper, M.; Görls, H.; Schneider, K. R. A.; Barnett, R.; Burks, T.; Neu, U.; Stallforth, P. |
| Source: |
ACS Chemical Biology 12 2017 , p. 2498 2502 |
| Publication Year: |
2017 |
| Collection: |
Helmholtz Zentrum Berlin (HZB): Publications |
| Subject Terms: |
Large scale facilities for research with photons neutrons and ions |
| Description: |
The class of cyclic lipopeptide natural products consists of compounds with a diverse range of bioactivities. In this study, we elucidated the structure of the cyclic lipopeptide anikasin using X ray crystallography, analyzed its biosynthetic gene cluster, and investigated its natural role in the interaction between the producer strain Pseudomonas fluorescens HKI0770 and protozoal predators. These results led to the conclusion that anikasin has dual functionality enabling swarming motility and acting as a niche amoebicide, which effectively inhibits the social amoeba Polysphondylium violaceum and protects the producer strain from protozoal grazing |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Availability: |
https://www.helmholtz-berlin.de/pubbin/oai_publication?VT=1&ID=113737 |
| Rights: |
info:eu-repo/semantics/closedAccess |
| Accession Number: |
edsbas.44C7E711 |
| Database: |
BASE |