| Title: |
The impact of chemotherapy on cognitive performance post-surgery in patients with colorectal cancer: A prospective cohort study |
| Authors: |
Dwek, M-R.; Newman, S. P.; Brini, S.; Holder, P.; Machesney, M.; Propper, D.; Rixon, L.; Hirani, S. P.; Hurt, C. S. |
| Publisher Information: |
Wiley |
| Publication Year: |
2023 |
| Collection: |
City University London: City Research Online |
| Subject Terms: |
BF Psychology; RC0254 Neoplasms. Tumors. Oncology (including Cancer); RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Description: |
Objectives Subjective reports of cognitive impairment following chemotherapy are frequent in cancer patients. Objective cognitive impairment has been observed in cancer patients regardless of treatment regimen suggesting the relationship between cognitive impairment and chemotherapy is not clear cut. Little research has explored the effects of chemotherapy on cognition following surgery in colorectal cancer(CRC). The present study explored the effects of chemotherapy on cognitive performance in a sample of CRC patients. Methods 136 participants were recruited into a prospective cohort study: 78 CRC patients undergoing surgery and adjuvant chemotherapy, 58 CRC patients undergoing surgery only. A battery of neuropsychological tests was administered to participants four weeks post-surgery(T1), twelve weeks after first chemotherapy(T2) and three months after last chemotherapy(T3) or equivalent time-points. Results Using the criterion of scoring at least two standard-deviations below the group norm on at least one neuropsychological test, 45%-55% of all CRC patients showed cognitive deficits ten months after surgery(T3) and 14% on at least 3 tests. However, cognition did not significantly differ between patients who had chemotherapy and those who did not. A time by group interaction effect was found on the composite cognition score using multi-level modelling suggesting a greater improvement in cognition in the surgery only group over time(p |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://openaccess.city.ac.uk/id/eprint/30495/3/Psycho-Oncology%20-%202023%20-%20Dwek%20-%20The%20impact%20of%20chemotherapy%20on%20cognitive%20performance%20post%E2%80%90surgery%20in%20patients%20with.pdf; https://openaccess.city.ac.uk/id/eprint/30495/1/POC%20Revised%20Manuscript%20Feb%2023%20Clean%20copy.docx; Dwek, M-R., Newman, S. P. https://openaccess.city.ac.uk/view/creators_id/stanton=2Enewman=2E1.html orcid:0000-0001-6712-6079 orcid:0000-0001-6712-6079 , Brini, S. https://openaccess.city.ac.uk/view/creators_id/stefano=2Ebrini.html , Holder, P., Machesney, M., Propper, D., Rixon, L., Hirani, S. P. https://openaccess.city.ac.uk/view/creators_id/shashi=2Ehirani=2E1.html orcid:0000-0002-1577-8806 orcid:0000-0002-1577-8806 Hurt, C. S. https://openaccess.city.ac.uk/view/creators_id/catherine=2Ehurt=2E1.html orcid:0000-0003-1571-0040 orcid:0000-0003-1571-0040 view all authorsEPJS_limit_names_shown_load( 'creators_name_30495_et_al', 'creators_name_30495_rest' ); (2023). The impact of chemotherapy on cognitive performance post-surgery in patients with colorectal cancer: A prospective cohort study. Psycho-Oncology, 32(7), pp. 1057-1066. doi:10.1002/pon.6147 https://doi.org/10.1002/pon.6147 |
| DOI: |
10.1002/pon.6147 |
| Availability: |
https://openaccess.city.ac.uk/id/eprint/30495/; https://openaccess.city.ac.uk/id/eprint/30495/1/POC%20Revised%20Manuscript%20Feb%2023%20Clean%20copy.docx; https://doi.org/10.1002/pon.6147 |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.44DF2BB4 |
| Database: |
BASE |