| Title: |
Latent change‐on‐change between amyloid accumulation and cognitive decline |
| Authors: |
Klinger, Hannah M.; Healy, Brian C.; Hanseeuw, Bernard; Jones, Rich N.; Boyle, Rory; Townsend, Diana L.; Properzi, Michael J.; Coughlan, Gillian T.; Seto, Mabel; Birkenbihl, Colin; Farrell, Michelle E.; Papp, Kathryn V.; Chhatwal, Jasmeer P.; Yang, Hyun‐Sik; Schultz, Aaron P.; Amariglio, Rebecca E.; Jacobs, Heidi I. L.; Price, Julie C.; Johnson, Keith A.; Rentz, Dorene M.; Sperling, Reisa A.; Buckley, Rachel F. |
| Contributors: |
UCL - SSS/IONS/NEUR - Clinical Neuroscience; UCL - (SLuc) Service de neurologie |
| Source: |
Alzheimer's & dementia, Vol. 20, no. 12, p. 8728-8738 (2024) |
| Publisher Information: |
John Wiley & Sons, Ltd. |
| Publication Year: |
2024 |
| Collection: |
DIAL@USL-B (Université Saint-Louis, Bruxelles) |
| Description: |
INTRODUCTION: While the influence of cross-sectional β-amyloid (Aβ) on longitudinal changes in cognition is well established, longitudinal change-on-change between Aβ and cognition is less explored. METHODS: A series of bivariate latent change score models (LCSM) examined the relationship between changes in 11C-Pittsburgh Compound-B (PiB) positron emission tomography (PET) and the Preclinical Alzheimer's Cognitive Composite-5 (PACC-5) while adjusting for covariates, including cross-sectional medial temporal lobe (MTL) tau-PET burden. We selected 352 clinically normal older participants with up to 9 years of PiB-PET and PACC-5 data from the Harvard Aging Brain Study (HABS). RESULTS: Aβ accumulation was associated with subsequent cognitive decline beyond the effects of cross-sectional Aβ burden. Within this model including covariates such as age, sex, and apolipoprotein ε4 (APOEε4) status, we found no evidence supporting previously published associations between cross-sectional tau-PET and cognitive intercept/slope. DISCUSSION: Short-term Aβ changes are significantly associated with cognitive decline in clinically normal older adults and may eclipse the effect of cross-sectional Aβ and MTL tau. HIGHLIGHTS: Aβ accumulation is associated with subsequent cognitive decline. High Aβ burden is not the sole metric signaling impending cognitive decline. Contrary to prior work, MTL tau-PET and cognition were not associated in our models. Models of bivariate latent Aβ and cognitive change may eclipse the effects of MTL tau. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
boreal:296682; https://hdl.handle.net/2078.1/296682; info:pmid/ |
| DOI: |
10.1002/alz.14326 |
| Availability: |
https://hdl.handle.net/2078.1/296682; https://doi.org/10.1002/alz.14326 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.451DC025 |
| Database: |
BASE |