| Title: |
Transcriptional regulation of murine natural killer cell development, differentiation and maturation. |
| Authors: |
Held, W.; Jeevan-Raj, B.; Charmoy, M. |
| Publication Year: |
2018 |
| Collection: |
Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| Subject Terms: |
Animals; CD11b Antigen/metabolism; Cell Differentiation; Cytokines/metabolism; Gene Expression Regulation; Killer Cells; Natural/cytology; Natural/metabolism; Lymphocytes/cytology; Lymphocytes/metabolism; Transcription Factors/metabolism; Tumor Necrosis Factor Receptor Superfamily; Member 7/metabolism; Cytokine; Cytokine receptor; Development; Differentiation; Innate lymphoid cells; Maturation; NK cells; Transcription factor |
| Description: |
Natural killer (NK) cells are innate cytotoxic effector cells that play important protective roles against certain pathogens as well as against pathogen-infected and transformed host cells. NK cells continuously arise from adult bone marrow-resident haematopoietic progenitors. Their generation can be sub-divided into three phases. The early NK cell development phase from multipotent common lymphoid progenitors occurs at least in part in common with that of additional members of a family of innate lymphoid cells, for which NK cells are the founding member. An intermediate phase of NK cell differentiation is characterized by the acquisition of IL-15 responsiveness and lineage-defining properties such as the transcription of genes coding for cytotoxic effector molecules. This is followed by a late maturation phase during which NK cells lose homeostatic expansion and increase effector capacity. These three phases are regulated by multiple stage-specific but not NK cell-specific transcription factors. This review summarizes the NK cell developmental and maturation processes and their transcriptional regulation with an emphasis on data derived from genetically modified mouse models. |
| Document Type: |
review |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
1420-9071 |
| Relation: |
Cellular and Molecular Life Sciences; https://iris.unil.ch/handle/iris/39526; serval:BIB_1E93DC8609A6; 000441912800006 |
| DOI: |
10.1007/s00018-018-2865-1 |
| Availability: |
https://iris.unil.ch/handle/iris/39526; https://doi.org/10.1007/s00018-018-2865-1 |
| Accession Number: |
edsbas.45383522 |
| Database: |
BASE |