| Title: |
Ultra‐Sharp Nanowire Arrays Natively Permeate, Record, and Stimulate Intracellular Activity in Neuronal and Cardiac Networks |
| Authors: |
Liu, Ren; Lee, Jihwan; Tchoe, Youngbin; Pre, Deborah; Bourhis, Andrew M; D'Antonio‐Chronowska, Agnieszka; Robin, Gaelle; Lee, Sang Heon; Ro, Yun Goo; Vatsyayan, Ritwik; Tonsfeldt, Karen J; Hossain, Lorraine A; Phipps, M Lisa; Yoo, Jinkyoung; Nogan, John; Martinez, Jennifer S; Frazer, Kelly A; Bang, Anne G; Dayeh, Shadi A |
| Source: |
Advanced Functional Materials, vol 32, iss 8 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2022 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
Engineering; Biomedical Engineering; cardiomyocytes; culture; intracellular; nanowires; neurons; tissues; cardiomyocyte; nanowire; neuron; tissue; Physical Sciences; Chemical Sciences; Materials |
| Description: |
We report innovative scalable, vertical, ultra-sharp nanowire arrays that are individually addressable to enable long-term, native recordings of intracellular potentials. Stable amplitudes of intracellular potentials from 3D tissue-like networks of neurons and cardiomyocytes are obtained. Individual electrical addressability is necessary for high-fidelity intracellular electrophysiological recordings. This study paves the way toward predictive, high-throughput, and low-cost electrophysiological drug screening platforms. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt5wv0s3k0; https://escholarship.org/uc/item/5wv0s3k0; https://escholarship.org/content/qt5wv0s3k0/qt5wv0s3k0.pdf |
| DOI: |
10.1002/adfm.202108378 |
| Availability: |
https://escholarship.org/uc/item/5wv0s3k0; https://escholarship.org/content/qt5wv0s3k0/qt5wv0s3k0.pdf; https://doi.org/10.1002/adfm.202108378 |
| Rights: |
public |
| Accession Number: |
edsbas.4539557E |
| Database: |
BASE |