| Title: |
Genome-wide Association Study of Long COVID |
| Authors: |
Lammi, Vilma; Nakanishi, Tomoko; Jones, Samuel E.; Andrews, Shea J.; Karjalainen, Juha; Cortés, Beatriz; O’Brien, Heath E.; Fulton-Howard, Brian E.; Haapaniemi, Hele H.; Schmidt, Axel; Mitchell, Ruth E.; Mousas, Abdou; Mangino, Massimo; Huerta-Chagoya, Alicia; Sinnott-Armstrong, Nasa; Cirulli, Elizabeth T.; Vaudel, Marc; Kwong, Alex S. F.; Maiti, Amit K.; Marttila, Minttu; Batini, Chiara; Minnai, Francesca; Dearman, Anna R.; Warmerdam, C. A. Robert; Sequeros, Celia B.; Winkler, Thomas W.; Jordan, Daniel M.; Guare, Lindsay; Vergasova, Ekaterina; Marouli, Eirini; Striano, Pasquale; Zainulabid, Ummu Afeera; Kumar, Ashutosh; Ahmad, Hajar Fauzan; Edahiro, Ryuya; Azekawa, Shuhei; Grzymski, Joseph J.; Ishii, Makoto; Okada, Yukinori; Beckmann, Noam D.; Kumari, Meena; Wagner, Ralf; Heid, Iris M.; John, Catherine; Short, Patrick J.; Magnus, Per; Banasik, Karina; Geller, Frank; Franke, Lude H.; Rakitko, Alexander; Duncan, Emma L.; Renieri, Alessandra; Tsilidis, Konstantinos K.; de Cid, Rafael; Niavarani, Ahmadreza; Tusié-Luna, Teresa; Verma, Shefali S.; Smith, George Davey; Timpson, Nicholas J.; Daly, Mark J.; Ganna, Andrea; Schulte, Eva C.; Richards, J. Brent; Ludwig, Kerstin U.; Hultström, Michael; Zeberg, Hugo; Ollila, Hanna M.; null, null |
| Contributors: |
V. Lammi; T. Nakanishi; S.E. Jone; S.J. Andrew; J. Karjalainen; B. Corté; H.E. O’Brien; B.E. Fulton-Howard; H.H. Haapaniemi; A. Schmidt; R.E. Mitchell; A. Mousa; M. Mangino; A. Huerta-Chagoya; N. Sinnott-Armstrong; E.T. Cirulli; M. Vaudel; A.S.F. Kwong; A.K. Maiti; M. Marttila; C. Batini; F. Minnai; A.R. Dearman; C.A.R. Warmerdam; C.B. Sequero; T.W. Winkler; D.M. Jordan; L. Guare; E. Vergasova; E. Marouli; P. Striano; U.A. Zainulabid; A. Kumar; H.F. Ahmad; R. Edahiro; S. Azekawa; J.J. Grzymski; M. Ishii; Y. Okada; N.D. Beckmann; M. Kumari; R. Wagner; I.M. Heid; C. John; P.J. Short; P. Magnu; K. Banasik; F. Geller; L.H. Franke; A. Rakitko; E.L. Duncan; A. Renieri; K.K. Tsilidi; R. de Cid; A. Niavarani; T. Tusié-Luna; S.S. Verma; G.D. Smith; N.J. Timpson; M.J. Daly; A. Ganna; E.C. Schulte; J.B. Richard; K.U. Ludwig; M. Hultström; H. Zeberg; H.M. Ollila; N. Null |
| Publication Year: |
2023 |
| Collection: |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: |
Post-acute sequelae of COVID-19 (PASC); Long COVID; Long-haul COVID-19; Post-COVID-19 syndrome; Post Covid Conditions (PCC); Long-term COVID-19 sequelae; FOXP4; Forkhead box transcription factor; GWAS; Meta-analysi; COVID-19; Genetic; Genomics; Settore MED/03 - Genetica Medica |
| Description: |
Infections can lead to persistent or long-term symptoms and diseases such as shingles after varicella zoster, cancers after human papillomavirus, or rheumatic fever after streptococcal infections1, 2. Similarly, infection by SARS-CoV-2 can result in Long COVID, a condition characterized by symptoms of fatigue and pulmonary and cognitive dysfunction3–5. The biological mechanisms that contribute to the development of Long COVID remain to be clarified. We leveraged the COVID-19 Host Genetics Initiative6, 7 to perform a genome-wide association study for Long COVID including up to 6,450 Long COVID cases and 1,093,995 population controls from 24 studies across 16 countries. We identified the first genome-wide significant association for Long COVID at the FOXP4 locus. FOXP4 has been previously associated with COVID-19 severity6, lung function8, and cancers9, suggesting a broader role for lung function in the pathophysiology of Long COVID. While we identify COVID-19 severity as a causal risk factor for Long COVID, the impact of the genetic risk factor located in the FOXP4 locus could not be solely explained by its association to severe COVID-19. Our findings further support the role of pulmonary dysfunction and COVID-19 severity in the development of Long COVID. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
numberofpages:25; https://hdl.handle.net/2434/1035328; https://www.medrxiv.org/content/10.1101/2023.06.29.23292056v1 |
| DOI: |
10.1101/2023.06.29.23292056 |
| DOI: |
10.1101/2023.06.29.23292056v1 |
| Availability: |
https://hdl.handle.net/2434/1035328; https://doi.org/10.1101/2023.06.29.23292056; https://www.medrxiv.org/content/10.1101/2023.06.29.23292056v1 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.45DF852C |
| Database: |
BASE |