| Title: |
International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis |
| Authors: |
Chen, Xin; Tsvetkov, Andrey; Shen, Han-Ming; Isidoro, Ciro; Ktistakis, Nicholas; Linkermann, Andreas; Koopman, Werner; Simon, Hans-Uwe; Galluzzi, Lorenzo; Luo, Shouqing; Xu, Daqian; Gu, Wei; Peulen, Olivier; Cai, Qian; Rubinsztein, David; Chi, Jen-Tsan; Zhang, Donna; Li, Changfeng; Toyokuni, Shinya; Liu, Jinbao; Roh, Jong-Lyel; Dai, Enyong; Juhasz, Gabor; Liu, Wei; Zhang, Jianhua; Yang, Minghua; Liu, Jiao; Zhu, Ling-Qiang; Zou, Weiping; Piacentini, Mauro; Ding, Wen-Xing; Yue, Zhenyu; Xie, Yangchun; Petersen, Morten; Gewirtz, David; Mandell, Michael; Chu, Charleen; Sinha, Debasish; Eftekharpour, Eftekhar; Zhivotovsky, Boris; Besteiro, Sébastien; Gabrilovich, Dmitry; Kim, Do-Hyung; Kagan, Valerian; Bayir, Hülya; Chen, Guang-Chao; Ayton, Scott; Lünemann, Jan; Komatsu, Masaaki; Krautwald, Stefan; Loos, Ben; Baehrecke, Eric; Wang, Jiayi; Lane, Jon; Sadoshima, Junichi; Yang, Wan Seok; Gao, Minghui; Münz, Christian; Thumm, Michael; Kampmann, Martin; Yu, Di; Lipinski, Marta; Jones, Jace; Jiang, Xuejun; Zeh, Herbert; Kang, Rui; Klionsky, Daniel; Kroemer, Guido; Tang, Daolin |
| Contributors: |
Guangzhou Medical University (GMU); The University of Texas Medical Branch (UTMB); McGovern Medical School Houston, Texas; University of Macau (UMac); Università degli Studi del Piemonte Orientale - Amedeo Avogadro (UPO); The Babraham Institute Cambridge, UK; Technische Universität Dresden = Dresden University of Technology (TU Dresden); Universität Bern = University of Bern = Université de Berne (UNIBE); Apoptose, cancer et immunité (U848); Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM); Peninsula Medical School; Plymouth University; Zhejiang University School of Medicine Hangzhou, China; Changzheng Hospital Shanghai; Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich (ULiège); Rutgers, The State University of New Jersey New Brunswick (RU); Rutgers University System (Rutgers); Cambridge Institute for Medical Research (CIMR); University of Cambridge Cambridge, UK (CAM); UK Dementia Research Institute (UK DRI); University College London UCL (UCL); Duke University Durham; University of Arizona; Aalto University; Nagoya University; CHA Bundang Medical Center; Jilin University (JLU); Eötvös Loránd Tudományegyetem = Eötvös Loránd University Budapest (ELTE); Renmin University of China = Université Renmin de Chine; MD Anderson Cancer Center Houston; The University of Texas Health Science Center at Houston (UTHealth); The Third Xiangya Hospital of Central South University Hunan, China (2TXH); Shanghai Jiao Tong University School of Medicine; Huazhong University of Science and Technology Wuhan (HUST); Université du Michigan = University of Michigan Ann Arbor (UMich); National Institute for Infectious Diseases "Lazzaro Spallanzani"; Università degli Studi di Roma Tor Vergata Roma, Italia = University of Rome Tor Vergata Rome, Italy = Université de Rome Tor Vergata Rome, Italie; University of Kansas Medical Center Kansas City, KS, USA; Departments of Neurology and Neuroscience; Icahn School of Medicine at Mount Sinai New York (MSSM); Central South University Changsha; Copenhagen University Hospital Denmark = Københavns Universitetshospital Danmark (KUH); Virginia Commonwealth University (VCU); The University of New Mexico Albuquerque; New Mexico Consortium (NMC); University of Pittsburgh (PITT); Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh School of Medicine; Johns Hopkins University Baltimore (JHU); University of Manitoba Winnipeg; Karolinska Institutet = Karolinska Institute Stockholm; Laboratory of Pathogen and Host Immunity Montpellier (LPHI); Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM); AstraZeneca; Korea Aerospace Research Institute Daejeon (KARI); Department of Critical Care Medicine; Pennsylvania Commonwealth System of Higher Education (PCSHE)-Pennsylvania Commonwealth System of Higher Education (PCSHE); Institute of Biological Chemistry Tapei (IBC Sinica); Academia Sinica; University of Melbourne; University Hospital Münster - Universitaetsklinikum Muenster Germany (UKM); Tokyo Metropolitan Institute of Medical Science (TMIMS); Christian-Albrechts-Universität zu Kiel = Christian-Albrechts University of Kiel = Université Christian-Albrechts de Kiel (CAU); Stellenbosch University (SU); University of Massachusetts Chan Medical School; The University of Edinburgh; University of Bristol Bristol; Rutgers New Jersey Medical School (NJMS); St. John’s University; Harbin Institute of Technology (HIT); University hospital of Zurich Zurich; Goettingen Center for Molecular Biosciences Goettingen, Germany; Goettingen Center for Molecular Biosciences Germany (GZMB)-Georg-August-University of Goettingen = Georg-August-Universität Göttingen; University of California (UC); University of Southern Queensland (USQ); University of Maryland Baltimore (UMB); Memorial Sloan Kettering Cancer Center (MSKCC); Department of Surgery, UT Southwestern Medical Center, Dallas, Texas, USA; Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)); École Pratique des Hautes Études (EPHE); Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité); Institut Gustave Roussy (IGR); Cancer Research and Personalized Medicine - CARPEM Paris (SIRIC CARPEM); Hôpital Européen Georges Pompidou APHP (HEGP); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpital Cochin AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Necker - Enfants Malades AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut national du cancer (INCa)-Université Paris Cité (UPCité); GK is supported by the Ligue contre le Cancer (équipe labellisée); Agence National de la Recherche (ANR-22-CE14-0066 VIVORUSH, ANR-23-CE44-0030 COPPERMAC, ANR-23-R4HC-0006 Ener-LIGHT); Association pour la recherche sur le cancer (ARC); Cancéropôle Ile-de-France; Fondation pour la Recherche Médicale (FRM); a donation by Elior; European Joint Programme on Rare Diseases (EJPRD) Wilsonmed; European Research Council Advanced Investigator Award (ERC-2021-ADG, Grant No. 101052444; project acronym: ICD-Cancer, project title: Immunogenic cell death (ICD) in the cancer-immune dialogue); The ERA4 Health Cardinoff Grant Ener-LIGHT; European Union Horizon 2020 research and innovation programmes Oncobiome (grant agreement number: 825410, Project Acronym: ONCOBIOME, Project title: Gut OncoMicrobiome Signatures GOMS associated with cancer incidence, prognosis and prediction of treatment response, Prevalung (grant agreement number 101095604, Project Acronym: PREVALUNG EU, project title: Biomarkers affecting the transition from cardiovascular disease to lung cancer: towards stratified interception), Neutrocure (grant agreement number 861878 : Project Acronym: Neutrocure; project title: Development of “smart” amplifiers of reactive oxygen species specific to aberrant polymorphonuclear neutrophils for treatment of inflammatory and autoimmune diseases, cancer and myeloablation); National support managed by the Agence Nationale de la Recherche under the France 2030 programme (reference number 21-ESRE-0028, ESR/Equipex+ Onco-Pheno-Screen); Hevolution Network on Senescence in Aging (reference HF-E Einstein Network); Institut National du Cancer (INCa); Institut Universitaire de France; LabEx Immuno-Oncology ANR-18-IDEX-0001; a Cancer Research ASPIRE Award from the Mark Foundation; PAIR-Obésité INCa_1873, the RHUs Immunolife and LUCA-pi (ANR-21-RHUS-0017 and ANR-23-RHUS-0010, both dedicated to France Relance 2030); Seerave Foundation; SIRIC Cancer Research and Personalized Medicine (CARPEM, SIRIC CARPEM INCa-DGOS-Inserm-ITMO Cancer_18006 supported by Institut National du Cancer, Ministère des Solidarités et de la Santé and INSERM). This study contributes to the IdEx Université de Paris Cité ANR-18-IDEX-0001.; ANR-18-IDEX-0001,Université de Paris,Université de Paris(2018); ANR-21-RHUS-0017,IMMUNOLIFE,Microbiota-centered interventions to solve antibiotics-induced primary resistance to immune checkpoint inhibitors(2021); ANR-21-ESRE-0028,ONCO-PHENO-SCREEN,Next-generation phenotypic screening for oncological applications(2021); ANR-22-CE14-0066,VIVORUSH,Le système RUSH : un système chemo-génétique pour la manipulation in vivo de circuits de communication.(2022); ANR-23-CE44-0030,COPPERMAC,Ciblage du cuivre mitochondrial pour moduler l'inflammation(2023); ANR-23-R4HC-0006,Ener-LIGHT,Energizing the failing heart(2023); ANR-23-RHUS-0010,LUCA-pi,Lung cancer prevention and interception(2023) |
| Source: |
ISSN: 1554-8627. |
| Publisher Information: |
CCSD; Taylor & Francis |
| Publication Year: |
2024 |
| Subject Terms: |
Cell death; ferritinophagy; iron; lipid peroxidation; lipophagy; lysosome; MESH: Ferroptosis; MESH: Humans; MESH: Autophagy; MESH: Animals; MESH: Consensus; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to. Ferroptosis is an iron-dependent oxidative form of cell death characterized by unrestricted lipid peroxidation in the context of heterogeneous and plastic mechanisms. Recent studies have shed light on the involvement of specific types of autophagy (e.g. ferritinophagy, lipophagy, and clockophagy) in initiating or executing ferroptotic cell death through the selective degradation of anti-injury proteins or organelles. Conversely, other forms of selective autophagy (e.g. reticulophagy and lysophagy) enhance the cellular defense against ferroptotic damage. Dysregulated autophagy-dependent ferroptosis has implications for a diverse range of pathological conditions. This review aims to present an updated definition of autophagy-dependent ferroptosis, discuss influential substrates and receptors, outline experimental methods, and propose guidelines for interpreting the results.Abbreviation: 3-MA:3-methyladenine; 4HNE: 4-hydroxynonenal; ACD: accidentalcell death; ADF: autophagy-dependentferroptosis; ARE: antioxidant response element; BH2:dihydrobiopterin; BH4: tetrahydrobiopterin; BMDMs: bonemarrow-derived macrophages; CMA: chaperone-mediated autophagy; CQ:chloroquine; DAMPs: danger/damage-associated molecular patterns; EMT,epithelial-mesenchymal transition; EPR: electronparamagnetic resonance; ER, endoplasmic reticulum; FRET: Försterresonance energy transfer; GFP: green fluorescent protein;GSH: glutathione;IF: immunofluorescence; IHC: immunohistochemistry; IOP, intraocularpressure; IRI: ischemia-reperfusion injury; LAA: linoleamide alkyne;MDA: malondialdehyde; PGSK: Phen Green™ SK;RCD: regulatedcell death; PUFAs: polyunsaturated fatty acids; RFP: red fluorescentprotein;ROS: reactive oxygen species; TBA: thiobarbituricacid; TBARS: thiobarbituric acid reactive substances; TEM:transmission electron microscopy. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/38442890; PUBMED: 38442890; PUBMEDCENTRAL: PMC11210914 |
| DOI: |
10.1080/15548627.2024.2319901 |
| Availability: |
https://inserm.hal.science/inserm-04841083; https://inserm.hal.science/inserm-04841083v2/document; https://inserm.hal.science/inserm-04841083v2/file/International%20consensus%20guidelines%20for%20the%20definition%20%20detection%20%20and%20interpretation%20of%20autophagy-dependent%20ferroptosis.pdf; https://doi.org/10.1080/15548627.2024.2319901 |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.4628BD5 |
| Database: |
BASE |