| Title: |
An interdisciplinary approach to characterize peanut‐allergic patients—First data from the FOOD@ consortium |
| Authors: |
Worm, Margitta; Alexiou, Aikaterina; Höfer, Veronika; Birkner, Till; Jeanrenaud, Alexander C. S. N.; Fauchère, Florent; Pazur, Kristijan; Steinert, Carolin; Arnau‐Soler, Aleix; Banerjee, Priyanka; Diefenbach, Andreas; Dobbertin‐Welsch, Josefine; Dölle‐Bierke, Sabine; Francuzik, Wojciech; Ghauri, Ahla; Heller, Stephanie; Kalb, Birgit; Löber, Ulrike; Marenholz, Ingo; Markó, Lajos; Scheffel, Jörg; Potapenko, Olena; Roll, Stephanie; Lau, Susanne; Lee, Young‐Ae; Braun, Julian; Thiel, Andreas; Babina, Magda; Altrichter, Sabine; Forslund, Sofia Kirke; Beyer, Kirsten |
| Publication Year: |
2022 |
| Collection: |
FU Berlin: Refubium |
| Subject Terms: |
biomarker; epigenetics; food allergy; microbiome; peanut allergy; ddc:610 |
| Description: |
Background: Peanut allergy is a frequent cause of food allergy and potentially life-threatening. Within this interdisciplinary research approach, we aim to unravel the complex mechanisms of peanut allergy. As a first step were applied in an exploratory manner the analysis of peanut allergic versus non-allergic controls. Methods: Biosamples were studied regarding DNA methylation signatures, gut microbiome, adaptive and innate immune cell populations, soluble signaling molecules and allergen-reactive antibody specificities. We applied a scalable systems medicine computational workflow to the assembled data. Results: We identified combined cellular and soluble biomarker signatures that stratify donors into peanut-allergic and non-allergic with high specificity. DNA methylation profiling revealed various genes of interest and stool microbiota differences in bacteria abundances. Conclusion: By extending our findings to a larger set of patients (e.g., children vs. adults), we will establish predictors for food allergy and tolerance and translate these as for example, indicators for interventional studies. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| DOI: |
10.17169/refubium-45602 |
| DOI: |
10.1002/clt2.12197 |
| Availability: |
https://refubium.fu-berlin.de/handle/fub188/45889; https://doi.org/10.17169/refubium-45602; https://doi.org/10.1002/clt2.12197 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.4699C02 |
| Database: |
BASE |