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Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes

Title:	Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes
Authors:	Holman R. R.; Bethel M. A.; Mentz R. J.; Thompson V. P.; Lokhnygina Y.; Buse J. B.; Chan J. C.; Choi J.; Gustavson S. M.; Iqbal N.; Maggioni A. P.; Marso S. P.; Ohman P.; Pagidipati N. J.; Poulter N.; Ramachandran A.; Zinman B.; Hernandez A. F. EXSCEL Study Group: Robert M Califf; Rishi Patel; Jyothis George; Harald Sourij; Yee Weng Wong; Karen Hannan; Mary Ann Sellers; Pat Gottlieb; Paula Lavender; Dianne Leloudis; Yolanda Meadows; Dan Larson; Heidi Anderson; Mary Elkins; Allegra Stone; Andrea Tisch; Lynn Perkins; Kesi Sanders; Curtis Campbell; Irene Kennedy; Paul Heal; Michelle Masterson; Julie Darbyshire; Lorraine Mumtaz; Rajbir Athwal; Andrea Ferch; Priyanka Batra; Lynne Durborow; Jennifer Vincent; Andrew Woodall; Terry Flanagan; Brian Katona; Barry Reicher; Emanuela Pozzi; Abderrahim Oulhaj; Ruth Coleman; Jean Lucien Rouleau; Stuart J Pocock; Fred Gorelick; John McMurray; Matt Riddle; Robert Gagel; Tim Collier; Tania Markovic; Alice Pik Shan Kong; Sim Kui Hian; Russell Scott; Araceli Panelo; Kun-Ho Yoon; Wayne Sheu; Piyamitr Sritara; Ji Linong; Chanyu Pan; Huo Yong; Guntram Schernthaner; Chantal Mathieu; Tsvetalina Tankova; Petr Widimsky; Markolf Hanefeld; Matyas Keltai; Julio Wainstein; Stefano del Prato; Valdis Pirags; Neli Jakuboniene; Adriaan Kooy; Piotr Dziemidok; Ioan Andrei Veresiu; Alexander V Dreval; Jan Murin; Albert LeCube Torello; Naveed Sattar; Olexander Parkhomenko; Mohamed Omar; Rafael Diaz; Renato Lopes; Fernando Lanas; Miguel Urina Triana; Jose Luis Leiva-Pons; David Aguliera; Richard Bergenstal; Shaun Goodman; Jean Francois Yale; Ian Caterson; Jianping Weng; Dayi Hu; Ge Junbo; Faiez Zannad; Misra Anoop; Mithal Ambrish; John Adaly Gallegos; Jennifer B Green; Axel Akerblom; Karen Alexander; Sana Al-Khatib; Luciana Armaganijan; Pedro Barros; Maria Batit; Gwen Bernacki; Sabrina Bernandez; Gerald Bloomfield; Emily Clausen; Flavio De Souza Brito; Adam DeVore; Keith Dombrowski; Zubin Eapen; Ziad Gellad; Daniel George; Patricia Guimaraes; Sharif Halim; Rob Harrison; Jodi Hawes; Connie Hess; Kristen Hyland; Larry Jackson; Schuyler Jones; Dedrick Jordan; Marcelo Katz; David Kong; Masaya Koshizaka; Wanda Lakey; Thomas LeBlanc; Sergio Leonardi; Nancy Luo; Ken Mahaffey; Aditya Mandawat; Rajendra Mehta; Chiara Melloni; Michael Morse; Neha Pagidpati; Chetan Patel; Keyur Patel; Sean Pokorney; Tom Posvic; Meena Rao; Matthew Roe; Bimal Shah; Hans Tillmann; Adriano Truffa; Yee-Weng Wong; Ana Zazula; Emily Zeitler; Maximiliano Sicer; Maria Rosa Ulla; Laura Maffei; Maria Isabel Klyver; Pedro Calella; Andrés Alvarisqueta; Ricardo Leon De La Fuente; Diego Aizenberg; Fernando Roque; Adrian Cruciani; Gustavo Frechtel; Elizabeth Gelersztein; Adriana Villarino; Marcelo Mallagray; Lucrecia Nardone; Cesar Zaidman; Leonardo Novaretto; Ines Bartolacci; Maria de Salvo; Candice Delcourt; Denis Crimmins; Richard Jackson; David O’Neal; Peter Colman; William Jeffries; Peak Mann Mah; Gary Wittert; Joseph Proietto; John Amerena; Sharon Marks; Ren Tan; David Colquhoun; Thomas Pieber; Heinz Drexel; Rudolf Prager; Christoph Schnack; Fredrich Hoppichler; Peter Fasching; Claudia Francesconi; Anton Luger; Hans-Robert Schoenherr; Christoph Ebenbichler; Bernhard Paulweber; Guntram Shernthaner; Ann Verhaegen; Johan Vanuytsel; Jean-Paul Thissen; Pedro Barros e Silva; Carolina Gonzaga; Joao Borges; Miguel Hissa; Rosangela Rea; Paulo Rossi; Antonio Chacra; Freddy Eliaschewitz; Benito Garbelini; Joao Felicio; Nelson Rassi; Fabio Rossi; Mayler Nunes dos Santos; Francisco Bandeira e Farias; Hugo Lisboa; Adriana Costa e Forti; José Kerr Saraiva; Snejina Kovacheva; Georgi Levterov; Galina Sheinkova; Elena Ilieva; Lyudmila Lyubenova; Velichka Damyanova; Valentina Gushterova; Lilyana Mincheva; Dimitar Illiev; Valentin Ivanov; Roza Bobeva; Zahari Nikitov; Rossitsa Shumkova; Ivaylp Nikolov Lefterov; Sabina Zaharieva; Vyara Videva; Andrian Yakov; Stephen Cheung; Thomas Elliott; Pravinsagar Mehta; Stuart Ross; Ronald Sigal; Vincent Woo; Shahin Jaffer; Robin Kuritsky; Alan Bell; Richard Dumas; Gilbert Gosselin; Yves Robitaille; Allen Greenspoon; Heather Lochnan; Richard Tytus; Jean-Francois Yale; Lawrence Leiter; Amritanshu Pandey; Zubin Punthakee; Francois Dube; John Sigalas; Murray Pearce; Timothy Woodford; Partha Paul; Ronald Bourgeois; Robin Conway; Guiseppe Mazza; Ronald Hatheway; Jack Misterski; Carlos Raffo; Claudia Olivares; Juan Godoy; Sergio Potthoff; Claudio Santibañez; Gladys Josefina Larenas Yanez; Wei Gu; Feixia Shen; Jianhua Ma; Xiaohui Guo; Qifu Li; Yuming Du; Ji Hu; Linong Ji; Yanbing Li; Hongyan Deng; Yingqing Feng; Ling Liu; Yiming Mu; Changsheng Ma; Shen Qu; Jiangzhong Wang; Yong Wang; Zuyi Yuan; Lihui Zhang; Shuxian Zhou; Tao Yang; Youping Dong; Dongfang Liu; Julian Coronel Arroyo; German Perez Amador; Rodrigo Botero Lopes; Carlos Jaramilo; Alejandro Orozco Linares; Carlos Alberto Cure Cure; Eric Hernandez Triana; Dora Inés Molina de Salazar; Catalina Rua Marin; Carlos Jose Jaramilo Gomez; Ivana Kellinerova; Vera Adamkova; Pavel Krami; Tomas Brychta; Jana Havelkova; Katarina Pantikova; Frank Schoper; Wilgard Pohl; Petra-Maria Schumm-Draeger; Ulrich Julius; Diethelm Tschöpe; Andreas Hamann; Jochen Seissler; Sebastian Schellong; Ludger Rose; Bernd Becker; Thomas Linn; Erika-Maria Oerter; Herman Josef Strotmann; Andrea Mölle; Andreas Pfutzner; Thomas Forst; Tim Schäufele; Andreas Mugge; Michael Lehrke; Ulrich Meyer-Pannwitt; Heidrun Mehling; Ilka Simon-Wagner; Isabelle Schenkenberger; Klaus Busch; Stephan Hermes; Karsten Milek; Bernhard Landers; Martin Grueneberg; Martin Braun; Jörg Nothroff; Wolfram Kamke; Gunter Hergdt; Hans-Dirk Duengen; Klaus Kleinertz; Detlev Kuesters; Agnes-Anette Himpel Boenninghoff; Karl-Fredrich Appel; Axel Schaefer; Tasso Bieler; Risa Ozaki; Andrea On Yan Luk; Daniel Wai-Sing Chu; Michelle Man-Ying Cheung-Wong; David Chung-Wah Siu; Bryan Ping Yen Yan; Kenny Kung; Samuel Yeung Shan Wong; Chiu-Chi Tsang; Vincent Tok-Fai Yeung; Bernard Man-Yeung Cheung; Hung Fat Tse; Gabriella Hodi; Karoly Nagy; Jozsef Lippai; Jozsef Takacs; Tibor Fulop; Zsolt Gaal; Zsolt Pauker; Iren Foldesi; Judit Simon; Tamas Oroszan; Laszlo Futo; Katalin Bezzegh; Andras Nagy; Gyozo Vandorfi; Julianna Kiss; Nora Kesmarki; Erno Kis; Janos Takacs; Andras Papp; Aranka Kovacs; Imre Szakal; Attila Palinkas; Zoltan Czegany; Peter Voros; Istvan Reiber; Zsuzsanna Kerenyi; Eniko Dezso; Istvan Wittman; Janos Penzes; Zsolt Ples; Andras Taller; Katalin Farago; János Tibor Kis; Zsolt Zilahi; Marta Molnar; László Barkai; Margit Mileder; Imre Szentpeteri; Eva Peterfai; Orsolva Lovasz; Ofri Mosenzon; Oscar Minuchin; Anat Jaffe; Victor Vishlitsky; Ilan Shimon; Amir Bashkin; Naftali Stern; Nizar Elias; Tamir Bental; Adi Butnaru; Basil Lewis; Faiad Adawi; William Nseir; Eliezer Klainman; Tommy Herskovits; Mauro Cignarelli; Carlo Maria Rotella; Guiseppe Ambrosio; Paolo Pozzilli; Stefano Genovese; Alessandro Cavarape; Alessandro Salvioni; Jelena Sokolova; Inese Strautina; Dace Teterovska; Valda Stalte; Sigita Pastare; Inta Leitane; Liga Lagzdina; Ilze Andersone; Ruta Eglite; Indra Stelmane; Andrej Levinger; Lina Barsiene; Marijona Sulskiene; Egle Varanauskiene; Evalda Danyte; Egle Urbanaviciene; Vaidotas Urbanavicius; Lina Zabuliene; Rasa Juskiene; Audrone Velaviciene; Vaida Kakariekiene; Audrone Augusteniene; Dzilda Velickiene; Jurate Lasiene; Dailia Dauksiene; Jonas Caponis; Alexander Tong-Boon Tan; Letchuman Ramanathan; Muhammad Radzi Abu Hassan; Florence Tan; Tiong Kiam Ong; Siew Hui Foo; Rohana Abdul Ghani; Wee Kooi Cheah; Jose-Luis Leiva-Pons; José Hector Sanchez Mijangos; Ricardo Cabrera Jardines; Margarita Barrientos Perez; Leobardo Sauque Reyna; Marco Antonio Alcocer Gamba; Efrain Villeda Espinosa; Hector Eloy Tamez Perez; Natalia Eloisa De La Garza Hernandez; Sigfrido Miracle Lopes; Santiago Paulino Ramirez Diaz; Roxana Reyes Sanchez; Eduardo Márquez-Rodriguez; Vicdan Köse; Christine Voors-Pette; P C Oldenburg-Ligtenberg; Willem Wouter van Kempen; Kevin Cox; Jacqueline Hoogendyk; Lindy Swinkels-Diepenmaat; Gloria Rojas-Lingan; Susanne Kentgens; Stefanie Schipperen; Harold Wessel de Valk; Henk Swart; B van Bemmel; P A M Hoogslag; Michaela Diamant; E H Serné; Andrew Hamer; Sam Wilson; Nicholas Fisher; Paul Dixon; Owais Chaudhri; Veronica Crawford; Dean Quinn; Kingsley Nirmalaraj; Peter Dunn; John Gillies; Rick Cutfield; Jeremy Krebs; Colin Helm; Jane Kerr; Jason Pryke; Geraldine Ebo; Marian Denopol; Ernesto Ang; Norbert Uy; Cecelia Jimeno; Roberto Mirasoi; Elizabeth Paz Pacheco; Myla Custodio; Nemencio Nicodemus Jr; Elizabeth Anne-Fernando Catindig; Marie Magno; Louie Tirador; Barbara Cylkowska; Teresa Stasinksa; Teresa Silwinska; Michal Sroka; Marek Piepiorka; Romuald Korzeniak; Hanna Mirecka; Roman Zaluska; Danuta Pupek-Musialik; Wojciech Homenda; Anna Grabowska; Boguslaw Okopien; Joanna Niegowska; Hanna Pogorzelska; Anna Mikolajczyk-Swatko; Marcin Sikorski; Dariusz Sowinski; Seung Jea Tahk; Yoon-Nyun Kim; Chang-Wook Nam; Se-Joong Rim; Chong-Jin Kim; Kyung Mook Choi; In Kyu Lee; In Joo Kim; June Namgung; Keon-Woong Moon; Kee-Sik Kim; Byung-Hee Oh; Won-Young Lee; Sung-Hee Choi; Eun Sook Kim; Sungdae Moon; Nicoleta Mihaela Mindrescu; Gheorgita Aron; Mariana Graur; Nicolae Hancu; Constantin Mlitaru; Valerica Nafornita; Iosif Szilagyi; Amorin Remus Popa; Liliana Monica Angelescu; Gabriela Doina Negrisanu; Daniela Gabriela Zaharie; Mirela Ioana Culman; Georgeta Vacaru; Mircea Munteanu; Silviana Constantinescu; Simona Tivadar; Alexander Dreval; Olga Barbarash; Leonid Strongin; Sergey Dogadin; Lyudmila Suplotova; Nadezhda Izmozherova; Vyacheslav Marasaev; Alexander Khokhlov; Alexey Repin; Elena Turova; Irina Bondar; Yulia Samoylova; Alexander Sherenkov; Olga Smolenskaya; Konstantin Zrahevskiy; Olga Koshelskaya; Andrey Obrezan; Andrej Dzupina; Jan Stevlik; Ingrid Buganova; Daniel Pella; Daniela Vinanska; Jaroslav Jascur; Karol Micko; Dalibor Sosovec; Adriana Philippiova; Peter Olexa; Jan Fedacko; Juraj Selecky; Joana Nicolau; Juan Mediavilla Garcia; Marta Botella Serrano; Albert Lecube; Iñaki Arguelles; José Sabán; Francisco Gómez Cerezo; Alfonso Soto; Diego Bellido; Nuria Sucunza Alfonso; Joan Vendrell Ortega; Luis Alvarez; Juan Garcia Puig; Maria Angustias Quesada; José Contreras Gilbert; Carlos Alexandre Almeida; Francisco José Tinahones; Luis Garcia Ortiz; Manuel Angel Gómez Marcos; Ismael Aomar; Mercè Fernández Balsells; Larry Distiller; Trevenesan Padayachee; Aysha Badat; Iftikar Ebrahim; Puvanesveri Naiker; Naresh Ranjith; Ynez Kelfkens; Hemantkumar Makan; Salphy Mogashoa; Muhammed Fulat; Nazira Carim-Ganey; Mahomed Omar; Kathleen Coetzee; Thirumani Govender; Hendrik Nortje; Agatha Wilhase; Saadiya Seedat; Mashra Gani; Graham Ellis; Paul Rheeder; Jeffrey Wing; Suzanne Blignaut; Hilton Kaplan; Hanlie Lottering; Perumal Pillai; Cheryl Louw; Thomas Coetzer; Wayne Huey Herng Sheu; Jung-Fu Chen; Chwen-Yi Yang; Shih-Ting Tseng; Chih-Yuan Wang; Wen-Ter Lai; Yi-Jen Hung; I-Chang Hsieh; Shih-Li Su; Dee Pei; Yupin Benjasuratwong; Tejpal Purewal; Anne Milward; Ioannis Dimitropoulos; Sudhesh Kumar; Thomas Barber; Philip Wiles; Chong Dang; Amanda Adler; Sam Philip; Srikanth Bellary; David Price; Ray Oelbaum; Simon Heller; Thozhukat Sathayapalan; John Clark; Graham Leese; Hamish Simpson; Anne Kilvert; Alison Dawson; Timothy Hall; Amrit Takhar; Charles Bundy; Peter Harvey; Sarah Maxwell; N Jaimeh Asamoah-Owusu; John McKnight; Sudesna Chatterjee; John Calvert; Anthony Wright; Sandra Macrury; David MacFarlane; Andrew Johnson; Jennifer Litchfield; Benjamin Field; Olena Koval; Oleksandr Larin; Olena Levchenko; Lilya Martynyuk; Vitaliy Maslyanko; Iurii Rudyk; Yevgen Suprun; Vira Tseluyko; Volodymyr Botsyurko; Mykola Vatutin; Ivan Fushtey; Olena Grishyna; Petro Kuskalo; Svitlana Panina; Larys Pererva; Liudmyla Prysupa; Zinaida Teliatnikova; Lyubov Sokolova; Maryna Vlasenko; Vadym Berenfus; Olga Gyrina; Mykola Kopytsya; Vadym Vizir; Myroslava Vayda; Michael Shanik; Dana Headapohl; Jorg Pahl; Stephen Aronoff; Anthony Bartkowiak Jr; Anna Chang; Linda Gaudiani; David Kayne; Michelle Look; Naynesh Patel; Joseph Moran; Elmer Stout; John Tsao; Russell Struble; Norman Fishman; Helena Rodbard; Kathryn Lucas; Pamela Dugano-Daphnis; Bryan Merrick; Venkatesh Nadar; Larry Severa; Chris Sorli; Mark Chang; John Reed III; George Grunberger; Catherine Bain; William Bestermann Jr; Emily Morawski; Judith White; Masoud Azizad; Philomena Ukwade; Adolphus Anekwe; Arthur Jimenez; Daniel Weiss; Sinikka Green; Jeffrey Overcash; Charles Eaton; Hal Roseman; Norman Soler; Frank Mikell; Paul Manos; Lawrence Levinson; Edmund Claxton Jr; Robert Weiss; Georges Argoud; Lauren Bickel; Jonathan Wilson; Brian Short; Brian Webster; Robert McNeill; Adrian Schnall; Rex Force; Lawrence Phillips; Kevin Bybee; Alan Forker; Douglas Denham; Thomas VonderHaar; John Pullman; Davida Kruger; Fred Whitehouse; Carol Wysham; Mira Baron; Alan Kravitz; Holly Dushkin; Mary Beth Manning; Alan Wine; Naseem Jaffrani; Chhavi Chadha; JoAnn Sperl-Hillen; Robert Busch; Roger Estevez; David Robbins; Negah Rassouli; Tim Garvey; Suzanne Oparil; Robert Eckel; Michael McDermott; Neda Rasouli; Janet McGill; Clinton Corder; David Klonoff; Richard Mills; John Earl; John Kessel; Robert Cuddihy; Robert Zimmerman; Priya Dayamani; Anne Chang; Elif Oral; Mark Zimering; Jennifer Marks; Kent Farnsworth; Danny Sugimoto; Philip Toth; Anuj Bhargava; Darren McGuire; Anand Rohatgi; Mark Davies; Eric Peden; Kathleen Wyne; Luis Alfonso; Berhane Seyoum; Basil Akpunonu; Mark Feinglos; Peter Reaven; Jeremy Soule; Louis Luttrell; Brian Schactman; Rafael Canadas; Bruce Boggs; Lisa Abbott; Charles Herring; Lon Roberts; Elie Hage-Korban; Ulrich Schubart; Alain Taylon; Alan Tannenbaum; Jeffrey Kingsley; James Lenhard; Mihaela Biscoveanu; Joshua Cohen; Daniel Donovan; Blandine Laferrere; Novelette Thompson; Thomas Wade; Robert Detweiler; Bruce Henson; Anthony White; Arvind Cavale; Chaitanya Ravi; Asha Thomas; Herbert Goodman; Vicki Kalen; Donald Fox; Ira Dauber; Syed Rizvi; Alan Marcus; Mim Mulford; Alexander Higgins; Majed Chane; Veita Bland; Abayomi Osunkoya; Damodhar Suresh; Salman Khan; Lawrence Anastasi; Mandeep Bajaj; Howard Eisen; Sunder Raj Mudaliar; Stephanie Powell; Kenneth Carr; Devjit Tripathy; Nasrin Azad; Paul Wakefield; Roger Acheatel; Peter Bressler; Julius Dean; Mahfouz El Shahawy; John Gilbert; Ihsan Haque; Daniel Humiston; Rodney Ison; Dennis Karounos; Michael Lillestol; Norman Ferrier; Ajay Labroo; Anthony Vo; Ronald D’Agostino; Michael Dulin; Andrew McWilliams; Joseph Hargrove; Edwin Blumberg; Bruce Jackson; Cezar Staniloae; Abraham Salacata; Horacio Hidalgo Jr; Philip Nicol; Michael DiGiovanna; Joseph Soufer; Vahid Mahabadi; Olakunle Akinboboye; Carlos Arauz-Pacheco; Joel Neutel; Kathleen Dungan; Mark Benson; Talessa Powell; Winston Gandy; Sergio Rovner; Martin Berk; Asma Khan; Gilbert Ledesma; Ivy Madu; Bernard Erickson; Mark Radbill; Mark Graves; Gregory Kaczmarek; Son Giep; Caryn Baldauf; Gordon Golden; Kurt Lesh; Cedrice Davis; Narendra Godbole; William Kirby; Naveed Razzaque; Bankim Bhatt; Matt Wilson
Contributors:	R. R., Holman; M. A., Bethel; R. J., Mentz; V. P., Thompson; Y., Lokhnygina; J. B., Buse; J. C., Chan; J., Choi; S. M., Gustavson; N., Iqbal; A. P., Maggioni; S. P., Marso; P., Ohman; N. J., Pagidipati; N., Poulter; A., Ramachandran; B., Zinman; EXSCEL Study Group: Robert M Califf, Hernandez A. F.; Patel, Rishi; George, Jyothi; Sourij, Harald; Weng Wong, Yee; Hannan, Karen; Ann Sellers, Mary; Gottlieb, Pat; Lavender, Paula; Leloudis, Dianne; Meadows, Yolanda; Larson, Dan; Anderson, Heidi; Elkins, Mary; Stone, Allegra; Tisch, Andrea; Perkins, Lynn; Sanders, Kesi; Campbell, Curti; Kennedy, Irene; Heal, Paul; Masterson, Michelle; Darbyshire, Julie; Mumtaz, Lorraine; Athwal, Rajbir; Ferch, Andrea; Batra, Priyanka; Durborow, Lynne; Vincent, Jennifer; Woodall, Andrew; Flanagan, Terry; Katona, Brian; Reicher, Barry; Pozzi, Emanuela; Oulhaj, Abderrahim; Coleman, Ruth; Lucien Rouleau, Jean; J Pocock, Stuart; Gorelick, Fred; Mcmurray, John; Riddle, Matt; Gagel, Robert; Collier, Tim; Markovic, Tania; Pik Shan Kong, Alice; Kui Hian, Sim; Scott, Russell; Panelo, Araceli; Yoon, Kun-Ho; Sheu, Wayne; Sritara, Piyamitr; Linong, Ji; Pan, Chanyu; Yong, Huo; Schernthaner, Guntram; Mathieu, Chantal; Tankova, Tsvetalina; Widimsky, Petr; Hanefeld, Markolf; Keltai, Matya; Wainstein, Julio; del Prato, Stefano; Pirags, Valdi; Jakuboniene, Neli; Kooy, Adriaan; Dziemidok, Piotr; Andrei Veresiu, Ioan; V Dreval, Alexander; Murin, Jan; LeCube Torello, Albert; Sattar, Naveed; Parkhomenko, Olexander; Omar, Mohamed; Diaz, Rafael; Lopes, Renato; Lanas, Fernando; Urina Triana, Miguel; Luis Leiva-Pons, Jose; Aguliera, David; Bergenstal, Richard; Goodman, Shaun; Francois Yale, Jean; Caterson, Ian
Publication Year:	2017
Collection:	IRIS UNIPV (Università degli studi di Pavia)
Subject Terms:	Aged; Cardiovascular Disease; Diabetes Mellitus; Type 2; Double-Blind Method; Drug Administration Schedule; Exenatide; Female; Human; Hypoglycemic Agent; Incidence; Injections; Subcutaneou; Kaplan-Meier Estimate; Least-Squares Analysi; Male; Middle Aged; Peptide; Venoms
Description:	BACKGROUND: The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown. METHODS: We randomly assigned patients with type 2 diabetes, with or without previous cardiovascular disease, to receive subcutaneous injections of extended-release exenatide at a dose of 2 mg or matching placebo once weekly. The primary composite outcome was the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke. The coprimary hypotheses were that exenatide, administered once weekly, would be noninferior to placebo with respect to safety and superior to placebo with respect to efficacy. RESULTS: In all, 14,752 patients (of whom 10,782 [73.1%] had previous cardiovascular disease) were followed for a median of 3.2 years (interquartile range, 2.2 to 4.4). A primary composite outcome event occurred in 839 of 7356 patients (11.4%; 3.7 events per 100 person-years) in the exenatide group and in 905 of 7396 patients (12.2%; 4.0 events per 100 person-years) in the placebo group (hazard ratio, 0.91; 95% confidence interval [CI], 0.83 to 1.00), with the intention-to-treat analysis indicating that exenatide, administered once weekly, was noninferior to placebo with respect to safety (P
Document Type:	article in journal/newspaper
Language:	English
Relation:	info:eu-repo/semantics/altIdentifier/pmid/28910237; info:eu-repo/semantics/altIdentifier/wos/WOS:000411838100006; volume:377; issue:13; firstpage:1228; lastpage:1239; numberofpages:12; journal:NEW ENGLAND JOURNAL OF MEDICINE; http://hdl.handle.net/11571/1341379
DOI:	10.1056/NEJMoa1612917
Availability:	http://hdl.handle.net/11571/1341379; https://doi.org/10.1056/NEJMoa1612917
Accession Number:	edsbas.46A06918
Database:	BASE