| Title: |
Determinants of anti-S immune response at 6 months after COVID-19 vaccination in a multicentric European cohort of healthcare workers – ORCHESTRA project |
| Authors: |
Collatuzzo G.; Visci G.; Violante F. S.; Porru S.; Spiteri G.; Monaco M. G. L.; Larese Fillon F.; Negro C.; Janke C.; Castelletti N.; De Palma G.; Sansone E.; Mates D.; Teodorescu S.; Fabianova E.; Beresova J.; Vimercati L.; Tafuri S.; Abedini M.; Ditano G.; Asafo S. S.; Boffetta P. |
| Contributors: |
G. Collatuzzo; G. Visci; F.S. Violante; S. Porru; G. Spiteri; M.G.L. Monaco; F. Larese Fillon; C. Negro; C. Janke; N. Castelletti; G. De Palma; E. Sansone; D. Mate; S. Teodorescu; E. Fabianova; J. Beresova; L. Vimercati; S. Tafuri; M. Abedini; G. Ditano; S.S. Asafo; P. Boffetta |
| Publisher Information: |
Frontiers Media S.A. |
| Publication Year: |
2022 |
| Collection: |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: |
COVID – 19; health care workers (HCW); immune response; serology; vaccine; Antibodie; Viral; Female; Health Personnel; Human; Immunity; Immunoglobulin G; Infant; Vaccination; COVID-19; COVID-19 Vaccines; Settore MEDS-25/B - Medicina del lavoro |
| Description: |
Background: The duration of immune response to COVID-19 vaccination is of major interest. Our aim was to analyze the determinants of anti-SARS-CoV-2 IgG titer at 6 months after 2-dose vaccination in an international cohort of vaccinated healthcare workers (HCWs). Methods: We analyzed data on levels of anti-SARS-CoV-2 Spike antibodies and sociodemographic and clinical characteristics of 6,327 vaccinated HCWs from 8 centers from Germany, Italy, Romania and Slovakia. Time between 1st dose and serology ranged 150-210 days. Serological levels were log-transformed to account for the skewness of the distribution and normalized by dividing them by center-specific standard errors, obtaining standardized values. We fitted center-specific multivariate regression models to estimate the cohort-specific relative risks (RR) of an increase of 1 standard deviation of log antibody level and corresponding 95% confidence interval (CI), and finally combined them in random-effects meta-analyses. Results: A 6-month serological response was detected in 99.6% of HCWs. Female sex (RR 1.10, 95%CI 1.00-1.21), past infection (RR 2.26, 95%CI 1.73-2.95) and two vaccine doses (RR 1.50, 95%CI 1.22-1.84) predicted higher IgG titer, contrary to interval since last dose (RR for 10-day increase 0.94, 95%CI 0.91-0.97) and age (RR for 10-year increase 0.87, 95%CI 0.83-0.92). M-RNA-based vaccines (p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/36248889; info:eu-repo/semantics/altIdentifier/wos/WOS:000868507400001; volume:13; firstpage:1; lastpage:11; numberofpages:11; journal:FRONTIERS IN IMMUNOLOGY; https://hdl.handle.net/2434/1209050; https://www.frontiersin.org/articles/10.3389/fimmu.2022.986085/full |
| DOI: |
10.3389/fimmu.2022.986085 |
| DOI: |
10.3389/fimmu.2022.986085/full |
| Availability: |
https://hdl.handle.net/2434/1209050; https://doi.org/10.3389/fimmu.2022.986085; https://www.frontiersin.org/articles/10.3389/fimmu.2022.986085/full |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.46BD41E3 |
| Database: |
BASE |