| Title: |
Thymic function is a major determinant of onset of antibody-mediated rejection in heart transplantation |
| Authors: |
Sannier A.; Stroumza N.; Caligiuri G.; Le Borgne-Moynier M.; Andreata F.; Senemaud J.; Louedec L.; Even G.; Gaston A. T.; Deschildre C.; Couvelard A.; Ou P.; Cheynier R.; Nataf P.; Dorent R.; Nicoletti A. |
| Contributors: |
Sannier, A; Stroumza, N; Caligiuri, G; Le Borgne-Moynier, M; Andreata, F; Senemaud, J; Louedec, L; Even, G; Gaston, A; Deschildre, C; Couvelard, A; Ou, P; Cheynier, R; Nataf, P; Dorent, R; Nicoletti, A |
| Publisher Information: |
Elsevier BV; NL |
| Publication Year: |
2018 |
| Collection: |
Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) |
| Subject Terms: |
basic (laboratory) research/science; heart (allograft) function/dysfunction; heart transplantation/cardiology; immunobiology; immunosuppressant - polyclonal preparations: rabbit antithymocyte globulin; monitoring: immune; rejection: antibody-mediated (ABMR); thymus/thymic biology; translational research/science; Settore MEDS-02/A - Patologia generale |
| Description: |
Thymic function decreases progressively with age but may be boosted in certain circumstances. We questioned whether heart transplantation was such a situation and whether thymic function was related to the onset of rejection. Twenty-eight antithymocyte globulin–treated heart transplant recipients were included. Patients diagnosed for an antibody-mediated rejection on endomyocardial biopsy had a higher proportion of circulating recent thymic emigrant CD4+ T cells and T cell receptor excision circle levels than other transplanted subjects. Thymus volume and density, assessed by computed tomography in a subset of patients, was also higher in patients experiencing antibody-mediated rejection. We demonstrate that thymic function is a major determinant of onset of antibody-mediated rejection and question whether thymectomy could be a prophylactic strategy to prevent alloimmune humoral responses. |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/29160947; info:eu-repo/semantics/altIdentifier/wos/WOS:000428844400022; volume:18; issue:4; firstpage:964; lastpage:971; numberofpages:8; journal:AMERICAN JOURNAL OF TRANSPLANTATION; https://hdl.handle.net/10281/425722 |
| DOI: |
10.1111/ajt.14595 |
| Availability: |
https://hdl.handle.net/10281/425722; https://doi.org/10.1111/ajt.14595 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Altro ; license uri:iris.PRI03 |
| Accession Number: |
edsbas.47226690 |
| Database: |
BASE |