| Title: |
Demographics and Clinical Assessment of Familial Multiple Sclerosis Patients in Ain Shams University Hospitals |
| Authors: |
Abdelaziz, Azza Abdel Nasser; ElSayed, Lobna Mohammed ElNabil; Swelam, Mahmoud Saad; Eldin, Nouran Mohammed Salah; Hamada, Hadeer Samir Ahmed |
| Source: |
QJM: An International Journal of Medicine ; volume 117, issue Supplement_2 ; ISSN 1460-2725 1460-2393 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2024 |
| Description: |
Background Multiple sclerosis (MS) is the most seen demyelinating disease. The exact cause of MS is still uncertain; many genes significantly increase the disease susceptibility along with several well-defined environmental factors. Genetic factors play an important role in the pathogenesis and clinical presentations of MS. Aim of the Work This study aims to detect the prevalence of familial multiple sclerosis among Egyptian patients suffering from MS at Ain Shams University hospitals, to register the demographics and the clinical characteristics of familial multiple sclerosis patients and to demonstrate the effect of inheritance on the severity and progression. Patients and Methods This study aimed to detect the prevalence of familial multiple sclerosis among Egyptian patients suffering from MS at Ain Shams University hospitals, to register the demographics and the clinical characteristics of familial multiple sclerosis patients and to demonstrate the effect of inheritance on the severity and progression. The current study showed that the prevalence of familial multiple sclerosis among MS Egyptian at Ain Shams University hospitals was 6,4%. Female to male percentages were found to be (73.8%) to (26.2%) respectively. Results The mean age of onset among the FMS cases was found to be (26.1±7.8). The mean time elapsed between symptoms onset and diagnosis was found to be (19.9±34.0) months and it was found that time from disease onset to MS diagnosis is significantly shorter in the 2nd and 3rd family-members diagnosed in familial cases compared to 1st family member diagnosed with MS. Regarding focality of presentation at the first attack, in this study there was found that monofocal presentation was more common than multifocal presentation (64.4%). The current study also showed that affection of the pyramidal functional system is significantly the most frequent in cases with an affected relative of first degree while it was least frequent in cases with an affected relative of third-degree consanguinity. ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/qjmed/hcae175.513 |
| Availability: |
https://doi.org/10.1093/qjmed/hcae175.513; https://academic.oup.com/qjmed/article-pdf/117/Supplement_2/hcae175.513/60746964/hcae175.513.pdf |
| Rights: |
https://academic.oup.com/pages/standard-publication-reuse-rights |
| Accession Number: |
edsbas.476E8CB8 |
| Database: |
BASE |