Core outcome set for surgical trials in gastric cancer (GASTROS study): international patient and healthcare professional consensus
| Title: | Core outcome set for surgical trials in gastric cancer (GASTROS study): international patient and healthcare professional consensus |
|---|---|
| Authors: | Alkhaffaf, B; Metryka, A; Blazeby, J M; Glenny, A-M; Adeyeye, A; Costa, P M; Diez Del Val, I; Gisbertz, S S; Guner, A; Law, S; Lee, H-J; Li, Z; Nakada, K; Reim, D; Vorwald, P; Baiocchi, G L; Allum, W; Chaudry, M A; Griffiths, E A; Williamson, P R; Bruce, I A; Li S.; He YL; Xu Z.; Xue Y.; Liang H.; Li G.; Zhao E.; Neumann P.; O’Neill L.; Guinan E.; Zanotti D.; de Manzoni G.; Hagens ERC.; van Berge Henegouwen MI.; Lages P.; Onofre S.; Restrepo Nunez RM.; Salcedo Cabanas G.; Posada Gonzalez M.; Marin Campos C.; Candas B.; Emre Baki B.; Selim Bodur M.; Yildirim R.; Burak Cekic A.; Brown J.; Hayes K.; Daher I.; Gianchandani Moorjani RH.; Adetoyese Adeyeye A.; Sulaiman Olayide A.; Mitsuo Leon-Takahashi A.; Pueyo Rabanal A.; Peri A.; Boddy A.; Novotny A.; Charalabopoulos A.; Alemdar A.; Souadka A.; Rodrigues Gomes AM.; Lazaro A.; Maciel Da Silva A.; do Rosario da Conceicao Silva e Santos A.; Guidi A.; Silva Bernardes AJ.; Quinn A.; Isik A.; A Slipek A.; Candas Altinbas B.; Johnson Alegbeleye B.; Wool Eom B.; Frittoli B.; Lonsdale B.; Rogers B.; Ammori BJ.; Rau B.; Molteni B.; Byrne BE.; Villacıs- Bermeo BA.; Villacıs Gallardo BE.; Kose B.; Sampedro Nogueira CJ.; Loureiro C.; Oliveira de Sousa CM.; Collins CG.; Nonso Ekwunife C.; Chukwunwendu Osuagwu C.; Wong CLY.; Winkler C.; Reim D.; Kjær DW.; Cooper D.; Horner D.; Irvine D.; Bowrey DJ.; Chuter DJ.; Elliot D.; McGhee D.; Toth D.; Ofner D.; Manatakis DK.; Silveira Martins DR.; Belt EJT.; Cattaneo E.; Samadov E.; Colak E.; Treppiedi E.; Guglielmi E.; Redondo- Villahoz E.; Ciferri E.; Tiemens-de Graaf E.; Cocozza E.; Pape E.; Drozdov ES.; Enrico F.; Rashid F.; Marco F.; Rosa F.; Mingol Navarro F.; Simionato Perrotta F.; Chan FSY.; Saavedra Tomasich FD.; Takeda FR.; Farrell F.; Olanike Wuraola F.; Rosero G.; Bevilacqua G.; Baronio G.; Mura G.; D’Eugenio G.; Ortega-Perez G.; Tilt G.; Sutcliffe G.; Mureddu G.; Guerra Jacob G.; Daneri H.; Olufemi Gbenga H.; Okabe H.; Kingsford Smith I.; Olawale Lateef I.; Garosio I.; Hatipoglu I.; Gockel I.; Negoi I.; Min ISH.; Mesquita IMM.; Diez del Val I.; Leemhuis JHF.; Gossage JA.; Weindelmayer J.; Izbicki JR.; McKenzie Manson J.; Kelly J.; Stoot JHMB.; Haveman JW.; Brown JD.; Sultan J.; Hassall J.; van Sandick J.; Saunders JH.; Clarke JK.; Heisterkamp J.; Vargas JI.; Couselo Villanueva JM.; Ingmire J.; McEwen J.; Galindo Alvarez J.; Turner J.; Peng J.; Roberts K.; Brandon KG.; Mitchell K.; McCarthy K.; Akhtar K.; Mikhailovich KN.; Corbelli L.; Medeiros Milhomem L.; Solaini L.; Fengyuan L.; Xinchun L.; Timmermans L.; Porritt L.; Taglietti L.; Bonavina L.; F. Pinheiro L.; de los Angeles Mayo Ossorio M.; Schiavo M.; Marchesiello M.; das Dores Vieira Leite M.; DeMois M.; Di Felice MT.; de Sousa MD.; Takahashi M.; Forshaw M.; Berselli M.; Paro M.; Usta MA.; Yan MH.; Pinchin M.; CapriolI M.; Rubbini M.; Cowen M.; Herrera Servin MA.; Li MZ.; Sasako M.; Shukri Jahit M.; Ngonyoku Muhinga M.; Tareen MA.; Ahmad MF.; Bodur MS.; Kaban M.; Farooq N.; Coburn N.; Cooper N.; Blencowe NS.; Loria N.; de Vries N.; Adami Andreollo N.; Koksal N.; Zanini N.; Kreuser N.; Okkabaz N.; Damiana O.; Afuwape O.; Kayode Fasiku O.; Comensoli O.; F. Koroye O.; Capener P.; Morgagni P.; Pernadas Lages PM.; Wilkerson PM.; Turner P.; Dutton P.; Hayes P.; Vorwald P.; Singh P.; Gan Q.; Kottayasamy Seenivasagam R.; Ayloor Seshadri R.; Guevara Castro R.; Douglas R.; Koshy RM.; Yıldırım R.; Skipworth RJE.; Gould RA.; Wetherill RC.; Shaw R.; Burley RA.; Palatucci R.; Racalbuto R.; Correia Casaca RM.; Lagarde SM.; Gana S.; Marietti S.; Qureshi S.; Morales-Conde S.; Molfino S.; Barreto SG.; Turkyilmaz S.; Turan-Trabzon S.; Frisch S.; Castoldi S.; Belloni S.; Flisi S.; Galloway S.; Maria SR.; Royston S.; Boyle T.; Sezer T.; Mengardo V.; Concepcion Martın V.; Lee Wills V.; Owen-Holt V.; Casagrande V.; Al-Khyatt W.; Jansen W.; Wang W.; Eshuis W.; Polkowski WP.; Huang X.; Wang X.; Chen XZ.; Gonzalez Dominguez Y.; Wang Y.; Viswanath YKS.; He YL.; Demir Z.; Na Z. |
| Contributors: | Alkhaffaf, B; Metryka, A; Blazeby, J M; Glenny, A-M; Adeyeye, A; Costa, P M; Diez Del Val, I; Gisbertz, S S; Guner, A; Law, S; Lee, H-J; Li, Z; Nakada, K; Reim, D; Vorwald, P; Baiocchi, G L; Allum, W; Chaudry, M A; Griffiths, E A; Williamson, P R; Bruce, I A; Li, S.; He, Yl; Xu, Z.; Xue, Y.; Liang, H.; Li, G.; Zhao, E.; Neumann, P.; O’Neill, L.; Guinan, E.; Zanotti, D.; de Manzoni, G.; Hagens, Erc.; van Berge Henegouwen, Mi.; Lages, P.; Onofre, S.; Restrepo Nunez, Rm.; Salcedo Cabanas, G.; Posada Gonzalez, M.; Marin Campos, C.; Candas, B.; Emre Baki, B.; Selim Bodur, M.; Yildirim, R.; Burak Cekic, A.; Brown, J.; Hayes, K.; Daher, I.; Gianchandani Moorjani, Rh.; Adetoyese Adeyeye, A.; Sulaiman Olayide, A.; Mitsuo Leon-Takahashi, A.; Pueyo Rabanal, A.; Peri, A.; Boddy, A.; Novotny, A.; Charalabopoulos, A.; Alemdar, A.; Souadka, A.; Rodrigues Gomes, Am.; Lazaro, A.; Maciel Da Silva, A.; do Rosario da Conceicao Silva e Santos, A.; Guidi, A.; Silva Bernardes, Aj.; Quinn, A.; Isik, A.; A Slipek, A.; Candas Altinbas, B.; Johnson Alegbeleye, B.; Wool Eom, B.; Frittoli, B.; Lonsdale, B.; Rogers, B.; Ammori, Bj.; Rau, B.; Molteni, B.; Byrne, Be.; Villacıs- Bermeo, Ba.; Villacıs Gallardo, Be.; Kose, B.; Sampedro Nogueira, Cj.; Loureiro, C.; Oliveira de Sousa, Cm.; Collins, Cg.; Nonso Ekwunife, C.; Chukwunwendu Osuagwu, C.; Wong, Cly.; Winkler, C.; Reim, D.; Kjær, Dw.; Cooper, D.; Horner, D.; Irvine, D.; Bowrey, Dj.; Chuter, Dj.; Elliot, D.; Mcghee, D.; Toth, D. |
| Publication Year: | 2021 |
| Collection: | Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS) |
| Subject Terms: | gastros; gastric cancer |
| Description: | Background: Surgery is the primary treatment that can offer potential cure for gastric cancer, but is associated with significant risks. Identifying optimal surgical approaches should be based on comparing outcomes from well designed trials. Currently, trials report different outcomes, making synthesis of evidence difficult. To address this, the aim of this study was to develop a core outcome set (COS)-a standardized group of outcomes important to key international stakeholders-that should be reported by future trials in this field.Methods: Stage 1 of the study involved identifying potentially important outcomes from previous trials and a series of patient interviews. Stage 2 involved patients and healthcare professionals prioritizing outcomes using a multilanguage international Delphi survey that informed an international consensus meeting at which the COS was finalized.Results: Some 498 outcomes were identified from previously reported trials and patient interviews, and rationalized into 56 items presented in the Delphi survey. A total of 952 patients, surgeons, and nurses enrolled in round 1 of the survey, and 662 (70 per cent) completed round 2. Following the consensus meeting, eight outcomes were included in the COS: disease-free survival, disease-specific survival, surgery-related death, recurrence, completeness of tumour removal, overall quality of life, nutritional effects, and 'serious' adverse events.Conclusion: A COS for surgical trials in gastric cancer has been developed with international patients and healthcare professionals. This is a minimum set of outcomes that is recommended to be used in all future trials in this field to improve trial design and synthesis of evidence. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34165555; info:eu-repo/semantics/altIdentifier/wos/WOS:000715383200039; volume:108; issue:10; firstpage:1216; lastpage:1224; numberofpages:9; journal:BRITISH JOURNAL OF SURGERY; https://hdl.handle.net/11562/1095651 |
| DOI: | 10.1093/bjs/znab192 |
| Availability: | https://hdl.handle.net/11562/1095651; https://doi.org/10.1093/bjs/znab192 |
| Rights: | info:eu-repo/semantics/restrictedAccess ; license:Non specificato ; license uri:na |
| Accession Number: | edsbas.478A2 |
| Database: | BASE |