| Title: |
Characteristics of Pediatric Ulcerative Colitis at Diagnosis in Korea: Results From a Multicenter, Registry-Based, Inception Cohort Study |
| Authors: |
Lim, JG; Kang, B; Oh, SH; Ryoo, E; Kim, YB; Choe, YH; Lee, YJ; Shin, M; Yang, HR; Kim, SC; Lee, YM; Koh, H; Park, JS; Choi, SY; Jeong, SJ; Lee, Y; Chang, JY; Kim, TH; Shim, JO; Moon, JS |
| Contributors: |
112955; Kim, YB |
| Publication Year: |
2024 |
| Subject Terms: |
Adolescent; Child; Cohort Studies; Colitis; Ulcerative; Female; Humans; Male; Registries; Republic of Korea; Severity of Illness Index; Korea; Ulcerative Colitis |
| Description: |
Background: We aimed to investigate the characteristics of pediatric ulcerative colitis (UC) at diagnosis in Korea. Methods: This was a multicenter, registry-based, inception cohort study conducted in Korea between 2021 and 2023. Children and adolescents newly diagnosed with UC < 18 years were included. Baseline clinicodemographics, results from laboratory, endoscopic exams, and Paris classification factors were collected, and associations between factors at diagnosis were investigated. Results: A total 205 patients with UC were included. Male-to-female ratio was 1.59:1, and the median age at diagnosis was 14.7 years (interquartile range 11.9–16.2). Disease extent of E1 comprised 12.2% (25/205), E2 24.9% (51/205), E3 11.2% (23/205), and E4 51.7% (106/205) of the patients. S1 comprised 13.7% (28/205) of the patients. The proportion of patients with a disease severity of S1 was significantly higher in patients with E4 compared to the other groups (E1: 0% vs. E2: 2% vs. E3: 0% vs. E4: 24.5%, P < 0.001). Significant differences between disease extent groups were also observed in Pediatric Ulcerative Colitis Activity Index (median 25 vs. 35 vs. 40 vs. 45, respectively, P < 0.001), hemoglobin (median 13.5 vs. 13.2 vs. 11.6 vs. 11.4 g/dL, respectively, P < 0.001), platelet count (median 301 vs. 324 vs. 372 vs. 377 × 103/μL, respectively, P = 0.001), C-reactive protein (median 0.05 vs. 0.10 vs. 0.17 vs. 0.38 mg/dL, respectively, P < 0.001), and Ulcerative Colitis Endoscopic Index of Severity (median 4 vs. 4 vs. 4 vs. 5, respectively, P = 0.006). No significant differences were observed in factors between groups divided according to sex and diagnosis age. Conclusion: This study represents the largest multicenter pediatric inflammatory bowel disease cohort in Korea. Disease severity was associated with disease extent in pediatric patients with UC at diagnosis. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
J010118934; http://repository.ajou.ac.kr/handle/201003/33595; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666324 |
| DOI: |
10.3346/jkms.2024.39.e303 |
| Availability: |
http://repository.ajou.ac.kr/handle/201003/33595; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666324; https://doi.org/10.3346/jkms.2024.39.e303 |
| Accession Number: |
edsbas.47BA6587 |
| Database: |
BASE |