Running Title: Suppression of somatostatin by hypergastrinemia. Corresponding Author
| Title: | Running Title: Suppression of somatostatin by hypergastrinemia. Corresponding Author |
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| Authors: | Yana Zavros; Gabriele Rieder; Amy Ferguson; Linda C. Samuelson; Juanita L; Juanita L. Merchant; Ph. D |
| Contributors: | The Pennsylvania State University CiteSeerX Archives |
| Source: | http://ajpgi.physiology.org/content/early/2001/10/17/ajpgi.00287.2001.full.pdf. |
| Collection: | CiteSeerX |
| Description: | Abbreviations: wild type mice (G+/+); gastrin-deficient mice (G-/-); G cells (gastrinexpressing cells); D cells (somatostatin-expressing cells); vehicle treated mice (V); omeprazole treated mice (OM); antibiotics (Abx); colony forming units (CFU). 1 Copyright 2001 by the American Physiological Society. Key Words: Helicobacter pylori, bacterial overgrowth, omeprazole, gastrin-null mice, mucosal lymphocytes. Background: Hypergastrinemia and a reduction in tissue somatostatin occur in Helicobacter pylori-infected patients. We investigated whether the D cell may be a direct target of gastric inflammation and hypergastrinemia. Methods: D cells were quantified by morphometry and flow cytometry in 16 week old wild type (G+/+) and gastrindeficient (G-/-) mice. Hypochlorhydric G-/- mice were treated with either antibiotics for 20 days or infused with gastrin (G-17) for 14 days. G+/+ mice were made hypochlorhydric by treating mice with omeprazole for 2 months. Results: G-/- mice showed significant inflammation when compared to the G+/+ mice which resolved after |
| Document Type: | text |
| File Description: | application/pdf |
| Language: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.7013; http://ajpgi.physiology.org/content/early/2001/10/17/ajpgi.00287.2001.full.pdf |
| Availability: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.7013; http://ajpgi.physiology.org/content/early/2001/10/17/ajpgi.00287.2001.full.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| Accession Number: | edsbas.47C22403 |
| Database: | BASE |