| Title: |
Concise Review: Prostate Cancer Stem Cells: Current Understanding |
| Authors: |
Skvortsov, Sergej; Skvortsova, Ira-Ida; Tang, Dean G.; Dubrovska, Anna |
| Contributors: |
Deutsche Forschungsgemeinschaft; DLR Project Management Agency; BMBF; U.S. National Institutes of Health; Department of Defense; Chinese Ministry of Science and Technology; RPCCC; NCI center; Austrian Science Fund; Austrian National Bank; Ingrid Shaker-Nessmann Cancer Research Foundation; DLR; National Institutes of Health; U.S. Department of Defense; NCI |
| Source: |
Stem Cells ; volume 36, issue 10, page 1457-1474 ; ISSN 1066-5099 1549-4918 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2018 |
| Description: |
Prostate cancer (PCa) is heterogeneous, harboring phenotypically diverse cancer cell types. PCa cell heterogeneity is caused by genomic instability that leads to the clonal competition and evolution of the cancer genome and by epigenetic mechanisms that result in subclonal cellular differentiation. The process of tumor cell differentiation is initiated from a population of prostate cancer stem cells (PCSCs) that possess many phenotypic and functional properties of normal stem cells. Since the initial reports on PCSCs in 2005, there has been much effort to elucidate their biological properties, including unique metabolic characteristics. In this Review, we discuss the current methods for PCSC enrichment and analysis, the hallmarks of PCSC metabolism, and the role of PCSCs in tumor progression. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1002/stem.2859 |
| Availability: |
https://doi.org/10.1002/stem.2859; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fstem.2859; https://onlinelibrary.wiley.com/doi/pdf/10.1002/stem.2859; https://onlinelibrary.wiley.com/doi/full-xml/10.1002/stem.2859; https://onlinelibrary.wiley.com/doi/am-pdf/10.1002/stem.2859; https://academic.oup.com/stmcls/article-pdf/36/10/1457/42606966/stmcls_36_10_1457.pdf |
| Rights: |
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model ; http://onlinelibrary.wiley.com/termsAndConditions#am ; http://onlinelibrary.wiley.com/termsAndConditions#vor ; http://doi.wiley.com/10.1002/tdm_license_1.1 |
| Accession Number: |
edsbas.47C7AD5D |
| Database: |
BASE |