| Title: |
Motion-selective cortical network is preserved in maculopathy patients |
| Authors: |
Michaud, Célia; Guenot, Jade; Faurite, Cynthia; Gallice, Mathilde; Chiquet, Christophe; Vayssière, Nathalie; Berry, Isabelle; Trotter, Yves; Soler, Vincent; Peyrin, Carole; Cottereau, Benoit |
| Contributors: |
Centre de recherche cerveau et cognition (CERCO UMR5549); Centre National de la Recherche Scientifique (CNRS)-Université de Toulouse (EPE UT); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Toulouse Mind & Brain Institut (TMBI); Université Toulouse - Jean Jaurès (UT2J); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Université de Toulouse (EPE UT); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Université Toulouse - Jean Jaurès (UT2J); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Université de Toulouse (EPE UT); Communauté d'universités et établissements de Toulouse (Comue de Toulouse); Laboratoire de Psychologie et NeuroCognition (LPNC); Université Savoie Mont Blanc (USMB Université de Savoie Université de Chambéry )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA); CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble (CHUGA); Centre Hospitalier Universitaire de Toulouse (CHU Toulouse); Image & Pervasive Access Lab (IPAL); National University of Singapore (NUS)-Agency for science, technology and research Singapore (A*STAR)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institute for Infocomm Research - I²R Singapore; ANR-21-CE28-0021,ReViS-MD,Réorganisations des capacités visuo-cognitives chez les patients atteints de dégénérescence maculaire(2021) |
| Source: |
GDR Vision ; https://hal.science/hal-05519347 ; GDR Vision, Jan 2025, Louvain-la-Neuve, Belgium |
| Publisher Information: |
CCSD |
| Publication Year: |
2025 |
| Collection: |
Université Toulouse 2 - Jean Jaurès: HAL |
| Subject Terms: |
[SCCO]Cognitive science |
| Subject Geographic: |
Louvain-la-Neuve; Belgium |
| Description: |
International audience ; Previous studies on animal models suggested that visual areas involved in motion processing could undergo important cortical reorganizations following damages to the central part of the retina. This could have major implications for patients suffering from macular degeneration (MD), the leading cause of vision loss in older adults. Here, we perform fMRI recordings in a group of maculopathy patients (including individuals suffering from age-related macular degeneration or from the Stargardt Disease) and in a group of age- and gender-matched controls to determine whether such reorganizations also exist in humans. We used an experimental protocol based on random-dot kinematograms (RDKs) classically employed to characterize motion-selective areas in the brain. To ensure that the visual information processed by the two groups was equivalent, the visual field in each control participant was masked using an artificial scotoma directly derived from clinical measurements in their paired patient. We found that in MD patients, translational motion elicited significant and robust activations in a restricted cortical network which included the human V5/MT+ complex (hMT+), areas V3A and V6 and a portion of primary visual areas (V1, V2 and V3) connected to peripheral vision. Importantly, the same patterns of responses were also observed in control participants. Moreover, the extent and strength of activation within these motion-selective areas did not differ significantly between the two groups. Altogether, these results suggest that in humans, the motion-selective network does not undergo significant cortical reorganizations following the onset of MD. |
| Document Type: |
conference object |
| Language: |
English |
| Availability: |
https://hal.science/hal-05519347 |
| Accession Number: |
edsbas.47CFE78 |
| Database: |
BASE |