Simvastatin in critically ill patients with Covid-19
| Title: | Simvastatin in critically ill patients with Covid-19 |
|---|---|
| Authors: | Hills, Thomas E; Lorenzi, Elizabeth; Berry, Lindsay R; Shyamsundar, Murali; Al-Beidh, Farah; Annane, Djillali; Arabi, Yaseen; Aryal, Diptesh; Au, Carly; Beane, Abigail; Bhimani, Zahra; Bonten, Marc; Bradbury, Charlotte A; Brunkhorst, Frank M; Burrell, Aidan; Buxton, Meredith; Calfee, Carolyn S; Cecconi, Maurizio; Cheng, Allen C; Cove, Matthew E; Detry, Michelle A; Estcourt, Lise J; Fitzgerald, Mark; Goligher, Ewan C; Goossens, Herman; Green, Cameron; Haniffa, Rashan; Harrison, David A; Hashmi, Madiha; Higgins, Alisa M; Huang, David T; Ichihara, Nao; Jayakumar, Deva; Kruger, Peter S; Lamontagne, François; Lampro, Lamprini; Lawler, Patrick R; Marshall, John C; Mason, Alexina J; McGlothlin, Anna; McGuinness, Shay; McQuilten, Zoe K; McVerry, Bryan J; Mouncey, Paul R; Murthy, Srinivas; Neal, Matthew D; Nichol, Alistair D; O'Kane, Cecilia M; Young, Ian S; McAuley, Daniel F |
| Source: | Hills, T E, Lorenzi, E, Berry, L R, Shyamsundar, M, Al-Beidh, F, Annane, D, Arabi, Y, Aryal, D, Au, C, Beane, A, Bhimani, Z, Bonten, M, Bradbury, C A, Brunkhorst, F M, Burrell, A, Buxton, M, Calfee, C S, Cecconi, M, Cheng, A C, Cove, M E, Detry, M A, Estcourt, L J, Fitzgerald, M, Goligher, E C, Goossens, H, Green, C, Haniffa, R, Harrison, D A, Hashmi, M, Higgins, A M, Huang, D T, Ichihara, N, Jayakumar, D, Kruger, P S, Lamontagne, F, Lampro, L, Lawler, P R, Marshall, J C, Mason, A J, McGlothlin, A, McGuinness, S, .... |
| Publication Year: | 2023 |
| Collection: | Queen's University Belfast: Research Portal |
| Description: | BACKGROUND: The efficacy of simvastatin in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear. METHODS: In an ongoing international, multifactorial, adaptive platform, randomized, controlled trial, we evaluated simvastatin (80 mg daily) as compared with no statin (control) in critically ill patients with Covid-19 who were not receiving statins at baseline. The primary outcome was respiratory and cardiovascular organ support-free days, assessed on an ordinal scale combining in-hospital death (assigned a value of -1) and days free of organ support through day 21 in survivors; the analyis used a Bayesian hierarchical ordinal model. The adaptive design included prespecified statistical stopping criteria for superiority (>99% posterior probability that the odds ratio was >1) and futility (>95% posterior probability that the odds ratio was |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 0028-4793 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37888913; info:eu-repo/semantics/altIdentifier/pissn/0028-4793 |
| DOI: | 10.1056/NEJMoa2309995 |
| Availability: | https://pure.qub.ac.uk/en/publications/5fda3edc-8099-41bf-adc1-6d7b99358b14; https://doi.org/10.1056/NEJMoa2309995; https://pureadmin.qub.ac.uk/ws/files/529366022/Hills_McAuley_23_09995_Text_PRODCOPY.pdf; https://www.scopus.com/pages/publications/85180969813 |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: | edsbas.47D2A31A |
| Database: | BASE |