| Title: |
Active Surveillance of Ductal Carcinoma In-Situ |
| Authors: |
Lin, Sophie Z; O’Keefe, Thomas J; Jackson, Jordan E; Hewitt, Kelly C; Esserman, Laura J |
| Source: |
Current Breast Cancer Reports, vol 18, iss 1 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2026 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
32 Biomedical and Clinical Sciences (for-2020); 3202 Clinical Sciences (for-2020); 3211 Oncology and Carcinogenesis (for-2020); Patient Safety (rcdc); Women's Health (rcdc); Comparative Effectiveness Research (rcdc); Clinical Research (rcdc); Cancer (rcdc); Precision Medicine (rcdc); Clinical Trials and Supportive Activities (rcdc); Breast Cancer (rcdc); Cancer (hrcs-hc); 3 Good Health and Well Being (sdg); Ductal carcinoma in-situ; DCIS; Active surveillance; Endocrine therapy; De-escalation; Overtreatment; 1112 Oncology and Carcinogenesis (for) |
| Description: |
Purpose of ReviewTailoring treatment strategies to the biological features of invasive disease and the individual needs and preference of each patient has transformed the way we manage breast cancer. This article calls for a similar shift in the management paradigm of ductal carcinoma in situ (DCIS) from a uniform treatment model toward a risk-stratified stepwise approach that aligns with the heterogeneous nature of the disease to avoid overtreatment.Recent FindingsMost DCIS lesions are hormone receptor positive, and only a subset have a risk for progression to invasive cancer. Early results from observational and clinical studies indicate that active surveillance is a safe and feasible alternative to upfront surgical treatment for low-risk DCIS. Ongoing clinical trials like RECAST will further inform and refine strategies for optimal management of this condition.SummaryThe integration of risk-adapted management strategies, endocrine risk-reducing interventions, and advanced imaging modalities into active surveillance protocols hold significant potential to reduce overtreatment and personalize care for patients with DCIS. Early data from clinical trials support the notion that providing a period of active surveillance is safe and offers a critical assessment window during which DCIS treatment can be individualized. Strengthening the evidence base to support the adoption of active surveillance as an initial approach in the management of DCIS is an important clinical priority. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt6v31q4sh; https://escholarship.org/uc/item/6v31q4sh; https://escholarship.org/content/qt6v31q4sh/qt6v31q4sh.pdf |
| DOI: |
10.1007/s12609-025-00609-x |
| Availability: |
https://escholarship.org/uc/item/6v31q4sh; https://escholarship.org/content/qt6v31q4sh/qt6v31q4sh.pdf; https://doi.org/10.1007/s12609-025-00609-x |
| Rights: |
CC-BY |
| Accession Number: |
edsbas.47D974D7 |
| Database: |
BASE |