| Title: |
Genomic characterisation of hormone receptor-positive breast cancer arising in very young women. |
| Authors: |
Luen, SJ; Viale, G; Nik-Zainal, S; Savas, P; Kammler, R; Dell'Orto, P; Biasi, O; Degasperi, A; Brown, LC; Láng, I; MacGrogan, G; Tondini, C; Bellet, M; Villa, F; Bernardo, A; Ciruelos, E; Karlsson, P; Neven, P; Climent, M; Müller, B; Jochum, W; Bonnefoi, H; Martino, S; Davidson, NE; Geyer, C; Chia, SK; Ingle, JN; Coleman, R; Solbach, C; Thürlimann, B; Colleoni, M; Coates, AS; Goldhirsch, A; Fleming, GF; Francis, PA; Speed, TP; Regan, MM; Loi, S |
| Publisher Information: |
Elsevier; Department of Medical Genetics; //doi.org/10.1016/j.annonc.2023.01.009 |
| Publication Year: |
2023 |
| Collection: |
Apollo - University of Cambridge Repository |
| Subject Terms: |
breast cancer; genomics; hormone receptor positive; prognosis; young women; Humans; Female; Aged; Breast Neoplasms; Erb-b2 Receptor Tyrosine Kinases; Class I Phosphatidylinositol 3-Kinases |
| Description: |
BACKGROUND: Very young premenopausal women diagnosed with hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+HER2-) early breast cancer (EBC) have higher rates of recurrence and death for reasons that remain largely unexplained. PATIENTS AND METHODS: Genomic sequencing was applied to HR+HER2- tumours from patients enrolled in the Suppression of Ovarian Function Trial (SOFT) to determine genomic drivers that are enriched in young premenopausal women. Genomic alterations were characterised using next-generation sequencing from a subset of 1276 patients (deep targeted sequencing, n = 1258; whole-exome sequencing in a young-age, case-control subsample, n = 82). We defined copy number (CN) subgroups and assessed for features suggestive of homologous recombination deficiency (HRD). Genomic alteration frequencies were compared between young premenopausal women ( |
| Document Type: |
article in journal/newspaper |
| File Description: |
Print-Electronic; application/pdf |
| Language: |
English |
| Relation: |
https://www.repository.cam.ac.uk/handle/1810/347212 |
| DOI: |
10.17863/CAM.94629 |
| Availability: |
https://www.repository.cam.ac.uk/handle/1810/347212; https://doi.org/10.17863/CAM.94629 |
| Rights: |
Attribution-NonCommercial-NoDerivatives 4.0 International ; https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.47FFA313 |
| Database: |
BASE |