Effects of Valproate in a Model Nervous System (Buccal Ganglia of Helix Pomatia): II. Epileptogenic Actions
| Title: | Effects of Valproate in a Model Nervous System (Buccal Ganglia of Helix Pomatia): II. Epileptogenic Actions |
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| Authors: | Altrup, U.; Reith, H.; Speckmann, E.‐J. |
| Source: | Epilepsia ; volume 33, issue 4, page 753-759 ; ISSN 0013-9580 1528-1167 |
| Publisher Information: | Wiley |
| Publication Year: | 1992 |
| Collection: | Wiley Online Library (Open Access Articles via Crossref) |
| Description: | Summary: High concentrations of valproate (VPA; ≥20 nM) depolarized identified neuronal individuals in the buccal ganglia of Hetix pomutia and transiently induced paroxysmal depolarization shifts (PDS). Threshold concentration of VPA for the induction of PDS was decreased (a) by increased seizure susceptibility, (b) by increased concentrations of derivatives of VPA, and (c) by increased H + concentrations. Intrasomatic injection of VPA did not induce PDS. The epileptogenic action of VPA is believed to be exerted from the extracellular side of the cell membrane. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| DOI: | 10.1111/j.1528-1157.1992.tb02357.x |
| Availability: | https://doi.org/10.1111/j.1528-1157.1992.tb02357.x; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1528-1157.1992.tb02357.x; https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1528-1157.1992.tb02357.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: | edsbas.48258EC0 |
| Database: | BASE |