Reactive Nanoparticles Derived from Polysaccharide Phenyl Carbonates
| Title: | Reactive Nanoparticles Derived from Polysaccharide Phenyl Carbonates |
|---|---|
| Authors: | Gericke, Martin; Geitel, Katja; Jörke, Cornelia; Clement, Joachim H.; Heinze, Thomas |
| Publication Year: | 2021 |
| Collection: | Digital Library Thüringen |
| Subject Terms: | article; ScholarlyArticle; ddc:540; polysaccharide derivatives; homogeneous synthesis; nanoparticles; xylan derivatives; biocompatibility; dye functionalization |
| Description: | Polysaccharide (PS) based nanoparticles (NP) are of great interest for biomedical applications. A key challenge in this regard is the functionalization of these nanomaterials. The aim of the present work was the development of reactive PS-NP that can be coupled with an amino group containing compounds under mild aqueous conditions. A series of cellulose phenyl carbonates (CPC) and xylan phenyl carbonates (XPC) with variable degrees of substitution (DS) was obtained by homogeneous synthesis. The preparation of PS-NP by self-assembling of these hydrophobic derivatives was studied comprehensively. While CPC mostly formed macroscopic aggregates, XPC formed well-defined spherical NP with diameters around 100 to 200 nm that showed a pronounced long-term stability in water against both particle aggregation as well as cleavage of phenyl carbonate moieties. Using an amino group functionalized dye it was demonstrated that the novel XPC-NP are reactive towards amines. A simple coupling procedure was established that enables direct functionalization of the reactive NP in an aqueous dispersion. Finally, it was demonstrated that dye functionalized XPC-NP are non-cytotoxic and can be employed in advanced biomedical applications. |
| Document Type: | article in journal/newspaper |
| File Description: | 13 Seiten |
| Language: | English |
| Relation: | Molecules -- 1420-3049 -- http://uri.gbv.de/document/gvk:ppn:311313132 -- 2008644-1 -- http://www.bibliothek.uni-regensburg.de/ezeit/?2008644 -- http://www.mdpi.com/journal/molecules; https://doi.org/10.3390/molecules26134026 |
| DOI: | 10.3390/molecules26134026 |
| Availability: | https://doi.org/10.3390/molecules26134026; https://nbn-resolving.org/urn:nbn:de:gbv:27-dbt-20210907-163614-002; https://www.db-thueringen.de/receive/dbt_mods_00049458; https://www.db-thueringen.de/servlets/MCRFileNodeServlet/dbt_derivate_00053977/molecules-26-04026.pdf |
| Rights: | https://creativecommons.org/licenses/by/4.0/ ; public ; info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.482FA9C6 |
| Database: | BASE |