| Title: |
Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study. |
| Authors: |
Hurst, EA; Mellanby, RJ; Handel, I; Griffith, DM; Rossi, AG; Walsh, TS; Shankar-Hari, M; Dunning, J; Homer, NZ; Denham, SG; Devine, K; Holloway, PA; Moore, SC; Thwaites, RS; Samanta, RJ; Summers, C; Hardwick, HE; Oosthuyzen, W; Turtle, L; Semple, MG; Openshaw, PJM; Baillie, JK; Russell, CD; ISARIC4C Investigators |
| Publisher Information: |
BMJ |
| Publication Year: |
2021 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
OBJECTIVES: The steroid hormone vitamin D has roles in immunomodulation and bone health. Insufficiency is associated with susceptibility to respiratory infections. We report 25-hydroxy vitamin D (25(OH)D) measurements in hospitalised people with COVID-19 and influenza A and in survivors of critical illness to test the hypotheses that vitamin D insufficiency scales with illness severity and persists in survivors. DESIGN: Cross-sectional study. SETTING AND PARTICIPANTS: Plasma was obtained from 295 hospitalised people with COVID-19 (International Severe Acute Respiratory and emerging Infections Consortium (ISARIC)/WHO Clinical Characterization Protocol for Severe Emerging Infections UK study), 93 with influenza A (Mechanisms of Severe Acute Influenza Consortium (MOSAIC) study, during the 2009-2010 H1N1 pandemic) and 139 survivors of non-selected critical illness (prior to the COVID-19 pandemic). Total 25(OH)D was measured by liquid chromatography-tandem mass spectrometry. Free 25(OH)D was measured by ELISA in COVID-19 samples. OUTCOME MEASURES: Receipt of invasive mechanical ventilation (IMV) and in-hospital mortality. RESULTS: Vitamin D insufficiency (total 25(OH)D 25-50 nmol/L) and deficiency ( |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
2044-6055 |
| Relation: |
https://hdl.handle.net/11343/301439 |
| Availability: |
https://hdl.handle.net/11343/301439 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Accession Number: |
edsbas.4878F032 |
| Database: |
BASE |