| Title: |
The association between sex hormones and the change in brain‐predicted age difference in older women |
| Authors: |
Wrigglesworth, Jo; Harding, Ian H.; Islam, Rakibul M.; Ward, Phillip G. D.; Woods, Robyn L.; Bell, Robin J.; McNeil, John J.; Storey, Elsdon; Egan, Gary; Murray, Anne M.; Trevaks, Ruth E.; Ward, Stephanie A.; Davis, Susan R.; Ryan, Joanne |
| Contributors: |
National Health and Medical Research Council |
| Source: |
Clinical Endocrinology ; volume 98, issue 5, page 692-699 ; ISSN 0300-0664 1365-2265 |
| Publisher Information: |
Wiley |
| Publication Year: |
2023 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Objective The role of circulating sex hormones on structural brain ageing is yet to be established. This study explored whether concentrations of circulating sex hormones in older women are associated with the baseline and longitudinal changes in structural brain ageing, defined by the brain‐predicted age difference (brain‐PAD). Design Prospective cohort study using data from NEURO and Sex Hormones in Older Women; substudies of the ASPirin in Reducing Events in the Elderly clinical trial. Patients Community‐dwelling older women (aged 70+ years). Measurements Oestrone, testosterone, dehydroepiandrosterone (DHEA), and sex‐hormone binding globulin (SHBG) were quantified from plasma samples collected at baseline. T1‐weighted magnetic resonance imaging was performed at baseline, 1 and 3 years. Brain age was derived from whole brain volume using a validated algorithm. Results The sample comprised of 207 women not taking medications known to influence sex hormone concentrations. A statistically higher baseline brain‐PAD (older brain age relative to chronological age) was seen for women in the highest DHEA tertile compared with the lowest in the unadjusted analysis ( p = .04). This was not significant when adjusted for chronological age, and potential confounding health and behavioural factors. Oestrone, testosterone and SHBG were not associated with brain‐PAD cross‐sectionally, nor were any of the examined sex hormones or SHBG associated with brain‐PAD longitudinally. Conclusion No strong evidence of an association between circulating sex hormones and brain‐PAD. Given there is prior evidence to suggests sex hormones may be important for brain ageing, further studies of circulating sex hormones and brain health in postmenopausal women are warranted. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/cen.14898 |
| Availability: |
https://doi.org/10.1111/cen.14898; https://onlinelibrary.wiley.com/doi/pdf/10.1111/cen.14898; https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cen.14898 |
| Rights: |
http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.48AA61E2 |
| Database: |
BASE |