| Title: |
GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets. |
| Authors: |
Dand, Nick; Stuart, Philip E; Bowes, John; Ellinghaus, David; Nititham, Joanne; Saklatvala, Jake R; Teder-Laving, Maris; Thomas, Laurent F; Traks, Tanel; Uebe, Steffen; Assmann, Gunter; Baudry, David; Behrens, Frank; Billi, Allison C; Brown, Matthew A; Burkhardt, Harald; Capon, Francesca; Chung, Raymond; Curtis, Charles J; Duckworth, Michael; Ellinghaus, Eva; FitzGerald, Oliver; Gerdes, Sascha; Griffiths, Christopher EM; Gulliver, Susanne; Helliwell, Philip S; Ho, Pauline; Hoffmann, Per; Holmen, Oddgeir L; Huang, Zhi-Ming; Hveem, Kristian; Jadon, Deepak; Köhm, Michaela; Kraus, Cornelia; Lamacchia, Céline; Lee, Sang Hyuck; Ma, Feiyang; Mahil, Satveer K; McHugh, Neil; McManus, Ross; Modalsli, Ellen H; Nissen, Michael J; Nöthen, Markus; Oji, Vinzenz; Oksenberg, Jorge R; Patrick, Matthew T; Perez White, Bethany E; Ramming, Andreas; Rech, Jürgen; Rosen, Cheryl; Sarkar, Mrinal K; Schett, Georg; Schmidt, Börge; Tejasvi, Trilokraj; Traupe, Heiko; Voorhees, John J; Wacker, Eike Matthias; Warren, Richard B; Wasikowski, Rachael; Weidinger, Stephan; Wen, Xiaoquan; Zhang, Zhaolin; BSTOP study group; Estonian Biobank research team; Barton, Anne; Chandran, Vinod; Esko, Tõnu; Foerster, John; Franke, Andre; Gladman, Dafna D; Gudjonsson, Johann E; Gulliver, Wayne; Hüffmeier, Ulrike; Kingo, Külli; Kõks, Sulev; Liao, Wilson; Løset, Mari; Mägi, Reedik; Nair, Rajan P; Rahman, Proton; Reis, André; Smith, Catherine H; Di Meglio, Paola; Barker, Jonathan N; Tsoi, Lam C; Simpson, Michael A; Elder, James T |
| Publisher Information: |
Springer Nature; //doi.org/10.1038/s41467-025-56719-8 |
| Publication Year: |
2025 |
| Collection: |
Apollo - University of Cambridge Repository |
| Subject Terms: |
Psoriasis; Humans; Genome-Wide Association Study; Genetic Predisposition to Disease; Alleles; Polymorphism; Single Nucleotide; Transcriptome |
| Description: |
Acknowledgements: We gratefully acknowledge the contributions of patients and family members, other research participants and clinical staff involved in recruitment. N.D. is funded by Health Data Research UK (MR/S003126/1). Support for the study was received from the Department of Health through the National Institute for Health and Care Research (NIHR) Bio-Resource Clinical Research Facility and comprehensive Biomedical Research Centre awards to Guy’s and St Thomas’ National Health Service Foundation Trust in partnership with King’s College London and King’s College Hospital National Health Service Foundation Trust (BRC_1215_20006). We acknowledge support from the Psoriasis Association in relation to Biomarkers of Systemic Treatment Outcomes in Psoriasis (RG2/10, RG2/10) and an award to P.D.M. (ST1/19) and FC (ST3/20). This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement number 821511 (Biomarkers in Atopic Dermatitis and Psoriasis). The JU receives support from the European Union’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). This publication reflects only the authors’ views and the JU is not responsible for any use that may be made of the information it contains. S.K.M. is funded by a NIHR Advanced Fellowship (NIHR302258). This study presents independent research supported by NIHR BioResource Centre Maudsley, NIHR Maudsley Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London. The BioResource gratefully acknowledge capital equipment funding from the Maudsley Charity (Grant Ref. 980) and Guy’s and St Thomas’s Charity (STR130505). P.D.M. reports a Translational Research Grant (814364) from the National Psoriasis Foundation. L.C.T. received funding from the National Institutes of Health (NIH) (K01 AR072129, P30 AR075043, UC2 AR081033). J.T.E. was ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf; text/xml; application/zip |
| Language: |
English |
| Relation: |
56719; https://www.repository.cam.ac.uk/handle/1810/380827 |
| Availability: |
https://www.repository.cam.ac.uk/handle/1810/380827 |
| Accession Number: |
edsbas.49085431 |
| Database: |
BASE |