| Title: |
Personality and quality-of-life improvement after apomorphine infusion in Parkinson's disease |
| Authors: |
Boussac, Mathilde; Harroch, Estelle; Barthelemy, Christel; Ory Magne, Fabienne; Leung, Clémence; Fabbri, Margherita; Arbus, Christophe; Brefel-Courbon, Christine |
| Contributors: |
Toulouse NeuroImaging Center (ToNIC); Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Toulouse Mind & Brain Institut (TMBI); Université Toulouse - Jean Jaurès (UT2J); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Université Toulouse - Jean Jaurès (UT2J); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse); Centre d’Excellence en Maladies Neurodégénératives (NeuroToul); Centre Hospitalier Universitaire de Toulouse (CHU Toulouse); Centre d'investigation clinique de Toulouse (CIC 1436); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Santé publique et médecine publique CHU Toulouse; Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse); Pôle Psychiatrie CHU Toulouse |
| Source: |
ISSN: 2632-1297 ; Brain Communications ; https://hal.science/hal-04602369 ; Brain Communications, 2024, 6 (3), pp.fcae181. ⟨10.1093/braincomms/fcae181/7681913⟩. |
| Publisher Information: |
CCSD; Oxford University Press on behalf of the Guarantors of Brain |
| Publication Year: |
2024 |
| Collection: |
Université Toulouse III - Paul Sabatier: HAL-UPS |
| Subject Terms: |
Precision Medicine; therapeutics; Temperament and Character Inventory; [SCCO.NEUR]Cognitive science/Neuroscience |
| Description: |
International audience ; People with Parkinson’s disease with motor fluctuations can be treated by Continuous Subcutaneous Apomorphine Infusion (CSAI) to reduce their symptoms. Nonetheless, factors are lacking to predict patients’ quality-of-life amelioration after CSAI. This pilot study aimed to evaluate associations between personality dimensions and quality-of-life improvement after six months of CSAI. Thirty-nine people with Parkinson’s disease awaiting CSAI were included. Linear regression models between “Temperament and Character Inventory” personality dimensions at baseline and percentage of change in PDQ-39 (Parkinson’s Disease Questionnaire-39) scores after six months of CSAI were realized (n = 35). Temperament and Character Inventory was also compared between patients awaiting CSAI and patients awaiting deep brain stimulation of the sub-thalamic nucleus (n = 39 from the PREDI-STIM study). Higher Reward Dependence scores were associated with a better quality-of-life outcome after six months of CSAI, while Self-Directedness scores were associated with a better quality of life before CSAI (as opposed to Harm Avoidance, Reward Dependence, and Self-Transcendence scores associated with a worse quality of life). Moreover, people with Parkinson’s disease awaiting deep brain stimulation of the sub-thalamic nucleus had similar Temperament and Character Inventory dimensions compared to patients awaiting CSAI. People with Parkinson’s disease with higher Reward Dependence scores at baseline had the best quality-of-life improvement after six months of CSAI. This finding could be used to better prepare and accompany people with Parkinson’s disease during CSAI establishment. Moreover, this result could serve as an orientation factor to second-line treatments. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/38846534; PUBMED: 38846534; PUBMEDCENTRAL: PMC11154139 |
| DOI: |
10.1093/braincomms/fcae181/7681913 |
| Availability: |
https://hal.science/hal-04602369; https://hal.science/hal-04602369v1/document; https://hal.science/hal-04602369v1/file/Boussac_2024.pdf; https://doi.org/10.1093/braincomms/fcae181/7681913 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.4950AD16 |
| Database: |
BASE |