| Title: |
Long COVID and cardiovascular disease: a prospective cohort study |
| Authors: |
Lawson, Claire Alexandra; Moss, Alastair James; Arnold, Jayanth Ranjit; Bagot, Catherine; Banerjee, Amitava; Berry, Colin; Greenwood, John; Hughes, Alun D.; Khunti, Kamlesh; Mills, Nicholas L.; Neubauer, Stefan; Raman, Betty; Sattar, Naveed; Leavy, Olivia C.; Richardson, Matthew; Elneima, Omer; McAuley, Hamish J.C.; Shikotra, Aarti; Singapuri, Amisha; Sereno, Marco; Saunders, Ruth; Harris, Victoria; Houchen-Wolloff, Linzy; Greening, Neil J.; Harrison, Ewen; Docherty, Annemarie B.; Lone, Nazir I.; Quint, Jennifer Kathleen; Chalmers, James; Ho, Ling Pei; Horsley, Alex; Marks, Michael; Poinasamy, Krisnah; Evans, Rachael; Wain, Louise V.; Brightling, Chris; McCann, Gerry P.; on behalf of the PHOSP-COVID Study Collaborative Group |
| Contributors: |
Crooks, Michael |
| Publisher Information: |
BMJ Publishing Group |
| Publication Year: |
2024 |
| Collection: |
University of Hull: Repository@Hull |
| Description: |
Background Pre-existing cardiovascular disease (CVD) or cardiovascular risk factors have been associated with an increased risk of complications following hospitalisation with COVID-19, but their impact on the rate of recovery following discharge is not known. Objectives To determine whether the rate of patient-perceived recovery following hospitalisation with COVID-19 was affected by the presence of CVD or cardiovascular risk factors. Methods In a multicentre prospective cohort study, patients were recruited following discharge from the hospital with COVID-19 undertaking two comprehensive assessments at 5 months and 12 months. Patients were stratified by the presence of either CVD or cardiovascular risk factors prior to hospitalisation with COVID-19 and compared with controls with neither. Full recovery was determined by the response to a patient-perceived evaluation of full recovery from COVID-19 in the context of physical, physiological and cognitive determinants of health. Results From a total population of 2545 patients (38.8% women), 472 (18.5%) and 1355 (53.2%) had CVD or cardiovascular risk factors, respectively. Compared with controls (n=718), patients with CVD and cardiovascular risk factors were older and more likely to have had severe COVID-19. Full recovery was significantly lower at 12 months in patients with CVD (adjusted OR (aOR) 0.62, 95% CI 0.43 to 0.89) and cardiovascular risk factors (aOR 0.66, 95% CI 0.50 to 0.86). Conclusion Patients with CVD or cardiovascular risk factors had a delayed recovery at 12 months following hospitalisation with COVID-19. Targeted interventions to reduce the impact of COVID-19 in patients with cardiovascular disease remain an unmet need. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://hull-repository.worktribe.com/output/4866674; Open Heart; Volume 11; Issue 1 |
| DOI: |
10.1136/openhrt-2024-002662 |
| Availability: |
https://hull-repository.worktribe.com/file/4866674/1/Published%20article; https://hull-repository.worktribe.com/output/4866674; https://doi.org/10.1136/openhrt-2024-002662 |
| Rights: |
openAccess ; http://creativecommons.org/licenses/by/4.0 |
| Accession Number: |
edsbas.496AE6A8 |
| Database: |
BASE |