| Title: |
Ibuprofen does not impair skeletal muscle regeneration upon cardiotoxin-induced injury. |
| Authors: |
Dalle, S; Poffé, C; Hiroux, C; Suhr, F; Deldicque, L; Koppo, K |
| Contributors: |
UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire |
| Source: |
Physiological research, Vol. 69, no.5, p. 847-859 (2020) |
| Publication Year: |
2020 |
| Collection: |
DIAL@USL-B (Université Saint-Louis, Bruxelles) |
| Subject Terms: |
Animals; Anti-Inflammatory Agents; Non-Steroidal; Cardiotoxins; Disease Models; Animal; Ibuprofen; Mice; Inbred C57BL; Muscle; Skeletal; Regeneration; Signal Transduction; Wound Healing |
| Description: |
Muscle regeneration is regulated through interaction between muscle and immune cells. Studies showed that treatment with supra-physiological doses of Non-Steroidal Anti-Inflammatory Drug (NSAID) abolished inflammatory signaling and impaired muscle recovery. The present study examines the effects of pharmacologically-relevant NSAID treatment on muscle regeneration. C57BL/6 mice were injected in the tibialis anterior (TA) with either PBS or cardiotoxin (CTX). CTX-injected mice received ibuprofen (CTX-IBU) or were untreated (CTX-PLAC). After 2 days, Il-1beta and Il-6 expression was upregulated in the TA of CTX-IBU and CTX-PL vs. PBS. However, Cox-2 expression and macrophage infiltration were higher in CTX-PL vs. PBS, but not in CTX-IBU. At the same time, anabolic markers were higher in CTX-IBU vs. PBS, but not in CTX-PL. Nevertheless, ibuprofen did not affect muscle mass or muscle fiber regeneration. In conclusion, mild ibuprofen doses did not worsen muscle regeneration. There were even signs of a transient improvement in anabolic signaling and attenuation of inflammatory signaling. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
boreal:269616; http://hdl.handle.net/2078.1/269616; info:pmid/32901495 |
| DOI: |
10.33549/physiolres.934482 |
| Availability: |
http://hdl.handle.net/2078.1/269616; https://doi.org/10.33549/physiolres.934482 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.498138F2 |
| Database: |
BASE |