| Title: |
Systematic review of peri-operative prognostic biomarkers in pancreatic ductal adenocarcinoma |
| Authors: |
Petrushnko, W; Gundara, JS; De Reuver, PR; O'Grady, G; Samra, JS; Mittal, A |
| Publisher Information: |
Elsevier |
| Publication Year: |
2016 |
| Collection: |
Griffith University: Griffith Research Online |
| Subject Terms: |
Clinical sciences; Endocrinology; Gastroenterology and hepatology |
| Description: |
Background: Pancreatic ductal adenocarcinoma (PDAC) continues to be associated with a poor prognosis. This systematic review aimed to summarize the literature regarding potential prognostic biomarkers to facilitate validation studies and clinical application. Methods: A systematic review was performed (2004–2014) according to PRISMA guidelines. Studies were ranked using REMARK criteria and the following outcomes were examined: overall/disease free survival, nodal involvement, tumour characteristics, metastasis, recurrence and resectability. Results: 256 biomarkers were identified in 158 studies. 171 biomarkers were assessed with respect to overall survival: urokinase-type plasminogen activator receptor, atypical protein kinase C and HSP27 ranked the highest. 33 biomarkers were assessed for disease free survival: CD24 and S100A4 were the highest ranking. 17 biomarkers were identified for lymph node involvement: Smad4/Dpc4 and FOXC1 ranked highest. 13 biomarkers were examined for tumour grade: mesothelin and EGFR were the highest ranking biomarkers. 10 biomarkers were identified for metastasis: p16 and sCD40L were the highest ranking. 4 biomarkers were assessed resectability: sCD40L, s100a2, Ca 19-9, CEA. Conclusion: This review has identified and ranked specific biomarkers that should be a primary focus of ongoing validation and clinical translational work in PDAC. ; No Full Text |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
HPB; Petrushnko, W; Gundara, JS; De Reuver, PR; O'Grady, G; Samra, JS; Mittal, A, Systematic review of peri-operative prognostic biomarkers in pancreatic ductal adenocarcinoma, HPB, 2016, 18 (8), pp. 652-663; https://hdl.handle.net/10072/388574 |
| DOI: |
10.1016/j.hpb.2016.05.004 |
| Availability: |
https://hdl.handle.net/10072/388574; https://doi.org/10.1016/j.hpb.2016.05.004 |
| Rights: |
open access |
| Accession Number: |
edsbas.49916A99 |
| Database: |
BASE |