| Title: |
Sensitization in organ transplantation: Assessment of Risk (STAR) 2025 meeting group report. |
| Authors: |
Schinstock, Carrie A; Gebel, Howard; Gimferrer, Idoia; Habal, Marlena; Heidt, Sebastiaan; Hickey, Michelle J; Jackson, Annette M; Kosmoliaptsis, Vasilis; Mannon, Roslyn B; Meneghini, Maria; Mengel, Michael; Morris, Anna; Naesens, Maarten; Reed, Elaine; Senev, Aleksandar; Thaunat, Olivier; Valenzuela, Nicole; Wiebe, Chris; Tambur, Anat R; STAR Working Group Members |
| Publisher Information: |
Elsevier; Department of Surgery; //doi.org/10.1016/j.ajt.2025.12.286 |
| Publication Year: |
2026 |
| Collection: |
Apollo - University of Cambridge Repository |
| Subject Terms: |
HLA laboratory; alloantibody; antibody-mediated rejection; donor-derived cell-free DNA; donor-specific antibody; molecular mismatch; natural killer cells; non-HLA antibody |
| Description: |
The Sensitization in Transplantation: Assessment of Risk initiative aimed to translate human leukocyte antibody (HLA) laboratory data into clinical practice and identify key knowledge gaps to guide future research. The Sensitization in Transplantation: Assessment of Risk working group has held 3 consensus meetings and published reports that have influenced clinical care. In 2025, the group focused on 5 evolving areas: donor-derived cell-free DNA tests, innate immunity in allograft rejection, immunogenicity and antigenicity, HLA antibody quantification, and non-HLA antibodies. Three years of work culminated in 2 webinars and a February 2025 community meeting, which are summarized in this report. The group outlined considerations for integrating donor-derived cell-free DNA tests into practice, proposed a definition for genetic prediction of natural killer-cell missing self, and discussed monocyte activation via the Signal-regulatory protein alpha - cluster of differentiation 47 (SIRPα-CD47) pathway. They reviewed molecular mismatch approaches, limitations, and immune-recognition complexities. Finally, they provided updates on HLA antibody quantification, non-HLA antibodies, and ongoing studies addressing critical knowledge gaps. |
| Document Type: |
article in journal/newspaper |
| File Description: |
Print-Electronic; application/pdf |
| Language: |
English |
| Relation: |
https://www.repository.cam.ac.uk/handle/1810/397559; https://doi.org/10.17863/CAM.126662 |
| DOI: |
10.17863/CAM.126662 |
| Availability: |
https://www.repository.cam.ac.uk/handle/1810/397559; https://doi.org/10.17863/CAM.126662 |
| Rights: |
Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.499E6DAB |
| Database: |
BASE |