| Title: |
Immune related proteins and tumor infiltratingCD8+ lymphocytes in hypopharyngeal cancer in relation to human papillomavirus (HPV) and clinical outcome |
| Authors: |
Landin, David; Ahrlund-Richter, Andreas; Mirzaie, Leila; Mints, Michael; Nasman, Anders; Kolev, Aeneas; Marklund, Linda; Dalianis, Tina; Munck-Wikland, Eva; Ramqvist, Torbjorn |
| Publisher Information: |
Umeå universitet, Urologi och andrologi; Departement of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel |
| Publication Year: |
2020 |
| Collection: |
Umeå University: Publications (DiVA) |
| Subject Terms: |
CD8-positive lymphocytes; clinical outcome; human papillomavirus; hypopharyngeal cancer; protein expression; Cancer and Oncology; Cancer och onkologi |
| Description: |
Background: Hypopharyngeal cancer (HPSCC) shows a poor clinical outcome, while HPSCC, caused by human papillomavirus (HPV), presents a better outcome. Here, HPCC, immune proteins, and tumor infiltrating CD8+ lymphocytes (CD8+ TILs) were evaluated in relation to HPV and outcome. Methods: Fresh frozen tissue from four HPV-positive HPSCC, 39 HPV-negative HPSCC, and normal samples were analyzed for protein expression by the Proseek immuno-oncology immunoassay. CD8+ TIL numbers evaluated by immunohistochemistry on 144 formalin-fixed biopsies were analyzed in relation to clinical outcome. Results: Proteins differing between HPV-positive and negative HPSCC included CD8A, PD-L1, Fas ligand, and chemokines. High CD8+ TIL numbers were correlated to improve clinical outcome in HPV-negative HPSCC. Conclusions: High expression of immune proteins in HPV-positive HPSCC may explain the better clinical outcome. CD8+ TILs are of relevance for outcome of HPV-negative HPSCC, while tumors with high immune activity but poor patient survival suggest a role for immune therapy. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISBN: |
978-0-00-544628-7; 0-00-544628-7 |
| Relation: |
Head and Neck, 1043-3074, 2020, 42:11, s. 3206-3217; PMID 32613643; ISI:000544628700001 |
| DOI: |
10.1002/hed.26364 |
| Availability: |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-173590; https://doi.org/10.1002/hed.26364 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.49BD2E47 |
| Database: |
BASE |