| Title: |
P-229. Epidemiology of Catheter-Related Bloodstream Infections in Italian Intensive Care Units: Data from the Italian Network for the Evaluation of ICU Interventions |
| Authors: |
Genovese, Camilla; Perego, Matilde; Scaglione, Giovanni; Palomba, Emanuele; Giordano, Giulia; Breschi, Valentina; De Nicolao, Giuseppe; Milanesi, Simone; Viaggi, Bruno; Gori, Andrea; Finazzi, Stefano; Colaneri, Marta |
| Source: |
Open Forum Infectious Diseases ; volume 12, issue Supplement_1 ; ISSN 2328-8957 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2025 |
| Description: |
Background Intensive care unit (ICU) acquired bloodstream infections (BSIs) are an important cause of morbidity and mortality. The use of invasive devices, such as endovascular catheters is associated with greater risk of developing such infections. Our study focuses on the epidemiology of ICU-acquired catheter-related BSIs (CR-BSIs) in Italy from 2014 to 2022.Table 1.Characteristics of ICU admitted patients from 2014 to 2022.LOS, length of stay; SD, standard deviation; CVC, central venous catheter; BSI, bloodstream infection; CR-BSI, catheter-related bloodstream infection. With intensive care treatment need we mean the number and percentage of patients who were admitted to ICU for intensive care treatment, therefore excluding those admitted for post-surgical monitoring or invasive procedure execution. Methods We retrieved data from the PROSAFE project, a prospective, observational, multicentric study involving 135 Italian ICUs. Clinical data were continuously collected by physicians from January 2014 to December 2022. CR-BSIs episodes were defined in accordance with the National Healthcare Safety Network. Multi-drug resistant Gram-negative bacteria (MDR-GNB) were defined as resistant to at least one carbapenem. Continuous variables were summarized with mean and standard deviation, while categorical data were presented as counts and percentages.Figure 1.Percentage of species isolated from blood cultures of patients with ICU-acquired catheter-related bloodstream infection from 2014 to 2022.S. aureus, Staphylococcus aureus; CoNS, Coagulase negative Staphylococci; GPB, Gram positive bacteria, GNB; Gram negative bacteria. Other GPB include Streptococci and Enterococci. Results A total of 271654 patients were included in our study (Table 1). The number of episodes of CR-BSIs was 3361. The in-ICU mortality of patients with CR-BSIs was 28.5%. The incidence of CR-BSIs slightly increased through the years (1.1% in 2014 vs 1.9% in 2022), peaking in 2020-2021. Regarding the microbiology, most bacteria were Gram ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/ofid/ofae631.433 |
| Availability: |
https://doi.org/10.1093/ofid/ofae631.433; https://academic.oup.com/ofid/article-pdf/12/Supplement_1/ofae631.433/61672277/ofae631.433.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.49C70B79 |
| Database: |
BASE |