| Title: |
Bisphosphonate-related osteonecrosis. Application of adipose-derived stem cells in an experimental murine model |
| Authors: |
Alonso Rodríguez, Estefanía; González Martín-Moro, Javier; Cebrián Carretero, José Luis; Castillo, José Luis del; Pozo Kreilinger, José Juan; Ruiz Bravo, Elena; García Arranz, Mariano Andrés; Hernández Godoy, Juan; Burgueño, Miguel |
| Contributors: |
Departamento de Anatomía Patológica; Departamento de Cirugía; Facultad de Medicina; Gobierno de España; Instituto de Salud Carlos III |
| Publisher Information: |
Medicina Oral |
| Publication Year: |
2026 |
| Collection: |
Universidad Autónoma de Madrid (UAM): Biblos-e Archivo |
| Subject Terms: |
Osteonecrosis; bisphosphonates; mesenchymal stem cells (MSC); adipose-derived stem cells (ASCs); zoledronic acid; Medicina |
| Description: |
Background: Bisphosphonate-related osteonecrosis of the jaw is a pathological condition without effective established treatment and preventive strategies. The aim of this study was to analyse the effect of adipose-derived stem cells (ASC) in an experimental murine model of osteonecrosis. Material and Methods: 38 Wistar rats were injected intraperitoneally with zoledronic acid. After treatment, upper jaw molars were extracted. The animals were randomly assigned to one of two groups. In the control group, saline solution was applied over the alveolar sockets after the tooth extractions. In the treatment group, ASCs were applied instead of saline solution. The control and treatment groups were subdivided based on the time of euthanasia. A clinical and histological analysis was performed. Results: The presence of osteonecrosis in alveolar bone was observed in a similar distribution in both groups. In the ASC-treated group, new bone formation was greater than in controls. Conclusions: In this study, application of ASCs showed greater new bone formation in an osteonecrosis-like murine model. Previous inhibited post-extraction bone remodelling could be reactivated, and these findings appeared to be secondary to implantation of ASCs ; This study was supported by a grant from the Fondo de Investigación Sanitaria (FIS), Spain |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
31232388 |
| Relation: |
Medicina Oral Patología Oral y Cirugía Bucal; https://doi.org/10.4317/medoral.22959; https://hdl.handle.net/10486/747920; e529; e536; 24; 22959 |
| DOI: |
10.4317/medoral.22959 |
| Availability: |
https://hdl.handle.net/10486/747920; https://doi.org/10.4317/medoral.22959 |
| Rights: |
© Medicina Oral S. L. ; open access |
| Accession Number: |
edsbas.49CC283D |
| Database: |
BASE |