| Title: |
Randomized controlled trial of an internet-based self-guided hand exercise program to improve hand function in people with systemic sclerosis: the Scleroderma Patient-centered Intervention Network Hand Exercise Program (SPIN-HAND) trial |
| Authors: |
Kwakkenbos, L; Carrier, ME; Welling, J; Levis, B; Levis, AW; Sauve, M; Turner, KA; Tao, L; Aguila, K; Carboni-Jiménez, A; Cañedo-Ayala, M; Harb, S; van den Ende, C; Hudson, M; van Breda, W; Nguyen, C; Boutron, I; Rannou, F; Thombs, BD; Mouthon, L; Henry, RS; Bartlett, SJ; Fortuné, C; Gottesman, K; Guillot, G; Hummers, LK; Lawrie-Jones, A; Malcarne, VL; Mayes, MD; Nielson, WR; Richard, M; Assassi, S; Benedetti, A; El-Baalbaki, G; Ells, C; Fligelstone, K; Frech, T; Gietzen, A; Harel, D; Hinchcliff, M; Johnson, SR; Larche, M; Leite, C; Nielsen, K; Pope, J; Sofia, T; Schouffoer, AA; Suarez-Almazor, ME; Agard, C; Abdallah, NA; André, M; Bernstein, EJ; Berthier, S; Bissonnette, L; Bruns, A; Carreira, P; Casadevall, M; Chaigne, B; Chung, L; Crichi, B; Denton, C; Domsic, R; Dunne, JV; Dunogue, B; Fare, R; Farge-Bancel, D; Fortin, PR; Gordon, J; Granel-Rey, B; Guffroy, A; Gyger, G; Hachulla, E; Herrick, AL; Hoa, S; Ikic, A; Jones, N; Kafaja, S; Khalidi, N; Lambert, M; Launay, D; Lee, YC; Maillard, H; Maltez, N; Manning, J; Marie, I; Lopez, MM; Martin, T; Masetto, A; Maurier, F; Mekinian, A; Díaz, SM; Nikpour, M; Olagne, L; Poindron, V; Proudman, S; Régent, A; Rivière, S; Robinson, D; Rodríguez, E; Roux, S |
| Publisher Information: |
Springer Science and Business Media LLC |
| Publication Year: |
2022 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
BACKGROUND: Systemic sclerosis (scleroderma; SSc) is a rare autoimmune connective tissue disease. Functional impairment of hands is common. The Scleroderma Patient-centered Intervention Network (SPIN)-HAND trial compared effects of offering access to an online self-guided hand exercise program to usual care on hand function (primary) and functional health outcomes (secondary) in people with SSc with at least mild hand function limitations. METHODS: The pragmatic, two-arm, parallel-group cohort multiple randomized controlled trial was embedded in the SPIN Cohort. Cohort participants with Cochin Hand Function Scale (CHFS) scores ≥ 3 and who indicated interest in using the SPIN-HAND Program were randomized (3:2 ratio) to an offer of program access or to usual care (targeted N = 586). The SPIN-HAND program consists of 4 modules that address (1) thumb flexibility and strength; (2) finger bending; (3) finger extension; and (4) wrist flexibility and strength. The primary outcome analysis compared CHFS scores 3 months post-randomization between participants offered versus not offered the program. Secondary outcomes were CHFS scores 6 months post-randomization and functional health outcomes (Patient-Reported Outcomes Measurement Information System profile version 2.0 domain scores) 3 and 6 months post-randomization. RESULTS: In total, 466 participants were randomized to intervention offer (N = 280) or usual care (N = 186). Of 280 participants offered the intervention, 170 (61%) consented to access the program. Of these, 117 (69%) viewed at least one hand exercise instruction video and 77 (45%) logged into the program website at least 3 times. In intent-to-treat analyses, CHFS scores were 1.2 points lower (95% CI - 2.8 to 0.3) for intervention compared to usual care 3 months post-randomization and 0.1 points lower (95% CI - 1.8 to 1.6 points) 6 months post-randomization. There were no statistically significant differences in other outcomes. CONCLUSION: The offer to use the SPIN-HAND Program did not improve hand function. ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
1745-6215 |
| Relation: |
https://hdl.handle.net/11343/334761 |
| Availability: |
https://hdl.handle.net/11343/334761 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Accession Number: |
edsbas.49ECB8FE |
| Database: |
BASE |