| Title: |
Heterogeneity of PD-MCI in Candidates to Subthalamic Deep Brain Stimulation: Associated Cortical and Subcortical Modifications. |
| Authors: |
Devignes, Quentin; Daoudi, S.; Viard, Romain; Lopes, Renaud; Betrouni, Nacim; Kuchcinski, Gregory; Rolland, A. S.; moreau, caroline; Defebvre, L.; Bardinet, E.; Bonnet, M.; Brefel-Courbon, C.; Delmaire, C.; Mountassir, F. E.; Fluchère, F.; Fradet, A.; Giordana, C.; Hainque, E.; Houvenaghel, J. F.; Jarraya, B.; Klinger, H.; Maltête, D.; Marques, A.; Meyer, M.; Rascol, O.; Rouaud, T.; Tir, M.; Wirth, T.; Corvol, J. C.; DEVOS, DAVID; Dujardin, Kathy; Daoudi, S |
| Contributors: |
Lille Neurosciences & Cognition - U 1172 LilNCog; Lille Neurosciences & Cognition (LilNCog) - U 1172; Plateformes Lilloises en Biologie et Santé - UAR 2014 - US 41 PLBS |
| Publication Year: |
2024 |
| Collection: |
LillOA (Lille Open Archive - Université de Lille) |
| Subject Terms: |
Cortical thickness; dual syndrome hypothesis; radiomics; shape analysis; voxel-based morphometry |
| Description: |
Background: Parkinson’s disease mild cognitive impairment (PD-MCI) is frequent and heterogenous. There is no consensus about its influence on subthalamic deep brain stimulation (STN-DBS) outcomes. Objective: To determine the prevalence of PD-MCI and its subtypes in candidates to STN-DBS. Secondarily, we sought to identify MRI structural markers associated with cognitive impairment in these subgroups. Methods: Baseline data from the French multicentric PREDISTIM cohort were used. Candidates to STN-DBS were classified according to their cognitive performance in normal cognition (PD-NC) or PD-MCI. The latter included frontostriatal (PD-FS) and posterior cortical (PD-PC) subtypes. Between-group comparisons were performed on demographical and clinical variables as well as on T1-weighted MRI sequences at the cortical and subcortical levels. Results: 320 patients were included: 167 (52%) PD-NC and 153 (48%) PD-MCI patients. The latter group included 123 (80%) PD-FS and 30 (20%) PD-PC patients. There was no between-group difference regarding demographic and clinical variables. PD-PC patients had significantly lower global efficiency than PD-FS patients and significantly worse performance on visuospatial functions, episodic memory, and language. Compared to PD-NC, PD-MCI patients had cortical thinning and radiomic-based changes in the left caudate nucleus and hippocampus. There were no significant differences between the PD-MCI subtypes. Conclusion: Among the candidates to STN-DBS, a significant proportion has PD-MCI which is associated with cortical and subcortical alterations. Some PD-MCI patients have posterior cortical deficits, a subtype known to be at higher risk of dementia. ; 12;5 |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/octet-stream |
| Language: |
English |
| Relation: |
Journal of Parkinson's disease; J Parkinsons Dis; http://hdl.handle.net/20.500.12210/95736 |
| Availability: |
https://hdl.handle.net/20.500.12210/95736 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.4A2B21F0 |
| Database: |
BASE |