| Title: |
Deep Brain Stimulation of the Subthalamic Nucleus as Adjunct Treatment for Refractory Epilepsy |
| Authors: |
Handforth, Adrian; DeSalles, Antonio A. F.; Krahl, Scott E. |
| Source: |
Epilepsia ; volume 47, issue 7, page 1239-1241 ; ISSN 0013-9580 1528-1167 |
| Publisher Information: |
Wiley |
| Publication Year: |
2006 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Summary: Purpose: We studied the efficacy and safety of bilateral subthalamic deep brain stimulation (DBS) for refractory partial‐onset epilepsy in two cases. Methods: This was an open treatment pilot study for subjects who had failed numerous medications and had seizure injuries. Seizure counts and adverse events were collected during a 3‐4 month baseline, and for 26‐32 months after DBS surgery, with AEDs held constant. Results: Case 1, age 45, with bitemporal seizures, had about half the seizure frequency but still fell with injuries. Case 2, age 46, with left frontal encephalomalacia, had a frequency reduction of about one‐third, but a more meaningful reduction of seizure severity and injuries. Conclusions: Subthalamic DBS partly reduced partial‐onset seizures, but the quality of life was more affected by seizure‐related injuries. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/j.1528-1167.2006.00563.x |
| Availability: |
https://doi.org/10.1111/j.1528-1167.2006.00563.x; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1528-1167.2006.00563.x; https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1528-1167.2006.00563.x |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.4A33BEAA |
| Database: |
BASE |